FINE STRUCTURAL ALTERATIONS OF THE BLOOD‐BRAIN BARRIER IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
FINE STRUCTURAL ALTERATIONS OF THE BLOOD‐BRAIN BARRIER IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
复制标题
实验性过敏性脑脊髓炎中血脑屏障的精细结构改变
DOI：
10.1097/00005072-197007000-00007
复制
发表时间：
1970
影响因子：
3.2
通讯作者：
H. M. Zimmerman
中科院分区：
文献类型：
--
作者：
A. Hirano;H. M. Dembitzer;N. Becker;S. Levine;H. M. Zimmerman
在对照组动物中，在血管周围或血管外间隙中未观察到示踪剂。在很大程度上，这是令人困惑的。1. EAE大鼠腰段脊髓血管的不透明切片。血管周围间隙和管腔（L）被密集的过氧化物酶反应产物渗透。胞饮小泡，充满过氧化物酶，可以看到在管腔（snall箭头）和基底（大箭头）表面。此外，较大的充满过氧化物酶的小囊在内皮细胞中也是可吸收的; X 70，000。Ttt. 2.类似于图1所示区域的未染色切片。管腔（L）和血管周围空间含有致密的反应产物。此外，在内皮细胞中可见到大的过氧化物酶填充结构; X 20，000。
RESULTSIn the control animals, the tracer was not observed in the perivascular or parenclıyınatous cxtracellular spaces. It was, for the most part, confincd toFt. 1. An unstinctl section of a blood vesscl in tlıc lumbar spinal cord of a rat subjccted to EAE. The perivascular space and the lumcn (L) are permeated with dense peroxidase reaction product. Pinocytotic vesicles, filled with peroxidase, may be seen at the luminal (snall arrow) and basal (large arrows) surfaces. In addition, larger peroxidasc-filled vicuoles: are visiblo witliin the endotlhelial cell; X 70,000. Ttt. 2. An utnstained section of an area similar to that illustrated in Figure 1. The lumen (L) and the perivascular space contain dense reaction product. In addition, large pcroxidasefillod structures may le seen in the endotihelial cclls; X 20,000.