Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD.
Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD.
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DOI：
10.1016/j.bonr.2016.10.005
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发表时间：
2016-12
期刊：
影响因子：
2.5
通讯作者：
Majumdar S
中科院分区：
文献类型：
--
作者：
Okazaki N;Burghardt AJ;Chiba K;Schafer AL;Majumdar S
本研究的主要目的是分析骨微观结构和强度与男性骨质疏松症危险因素（包括年龄、体重指数、血清25-羟基维生素D水平和睾酮水平）之间的关系。第二个目的是比较正常、低和骨质疏松范围骨密度（aBMD）男性之间的微观结构和强度参数。招募了78名健康男性志愿者（平均年龄62.4 ± 7.8岁，范围50-84岁）。参与者接受双能X线骨密度仪（DXA）和高分辨率外周定量计算机断层扫描（HR-pQCT）的超远端桡骨和胫骨。根据HR-pQCT图像，评价体积骨矿物质密度（BMD）以及皮质骨和松质骨显微结构，并使用微观有限元分析（μFEA）估计骨强度和皮质骨负荷分数（Ct.LF）。年龄与骨微结构的相关性比其他风险因素更强。年龄与桡骨远端和胫骨的骨皮质孔隙度呈显著正相关（分别为r = 0.36，p = 0.001和r = 0.47，p < 0.001）。在胫骨，年龄与皮质骨密度呈负相关，而与骨小梁骨密度呈正相关。在μFEA中，年龄与Ct.LF呈负相关，但与骨强度无关。与正常aBMD的男性相比，低或骨质疏松范围aBMD的男性在两个部位的骨小梁显微结构和骨强度均显著较差，而皮质骨无显著差异。皮质骨微结构受到老化的负面影响，并且有一种观点认为，老化的影响在负重部位可能特别重要。通过HR-pQCT分析超远端桡骨和胫骨的骨显微结构。受试者包括78名健康男性志愿者，年龄从50岁到84岁不等。与松质骨相比，皮质骨随着年龄的增长受损更严重。皮质骨孔隙率随年龄增长而增加，尤其是在胫骨超远端。
The primary objective of this study was to analyze the relationships between bone microstructure and strength, and male osteoporosis risk factors including age, body mass index, serum 25-hydroxyvitamin D level, and testosterone level. A secondary objective was to compare microstructural and strength parameters between men with normal, low, and osteoporosis-range areal bone mineral density (aBMD). Seventy-eight healthy male volunteers (mean age 62.4 ± 7.8 years, range 50–84 years) were recruited. The participants underwent dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) of the ultra-distal radius and tibia. From the HR-pQCT images, volumetric bone mineral density (BMD) and cortical and trabecular bone microstructure were evaluated, and bone strength and cortical load fraction (Ct.LF) were estimated using micro-finite element analysis (μFEA). Age was more strongly correlated with bone microstructure than other risk factors. Age had significant positive correlations with cortical porosity at both ultra-distal radius and tibia (r = 0.36, p = 0.001, and r = 0.47, p < 0.001, respectively). At the tibia, age was negatively correlated with cortical BMD, whereas it was positively correlated with trabecular BMD. In μFEA, age was negatively correlated with Ct.LF, although not with bone strength. Compared with men with normal aBMD, men with low or osteoporosis-range aBMD had significantly poor trabecular bone microstructure and lower bone strength at the both sites, while there was no significant difference in cortical bone. Cortical bone microstructure was negatively affected by aging, and there was a suggestion that the influence of aging may be particularly important at the weight-bearing sites. Bone microstructure of the ultra-distal radius and tibia was analyzed by HR-pQCT. The subjects consisted of 78 healthy male volunteers ranging from 50 to 84 years. Cortical bone was more impaired with age compared with trabecular bone. Cortical porosity was increased with age, particularly at the ultra-distal tibia.