Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia
Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia
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DOI：
10.1021/jf800416j
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发表时间：
2008-07-09
影响因子：
6.1
通讯作者：
Piacente, Sonia
中科院分区：
文献类型：
--
作者：
Masullo, Milena;Bassarello, Carla;Piacente, Sonia
鉴于藤黄酚具有广泛的生物活性，为了探索其部分生物活性，我们从藤黄果实中进行了分离。令人惊讶的是，这些水果中还发现了古蒂费酮I、J和K，这是海葵中从未报道过的化合物，以及三个新的化合物，分别是古蒂费酮M(1)、古蒂佛酮N(2)和古提佛酮K的氧化衍生物(6)。氧基二苯甲酮K(6)是由天然来源的聚异戊二烯基二苯甲酮氧化而来的第一个四环杂多酮的例子。氧基古替菲酮K的自然形成与DPPH环化甘草酚的过程相一致。
In light of the wide range of biological activities of garcinol and with the aim of exploring some of them, we carried out its isolation from the fruits of Garcinia cambogia L. (Guttiferae). Surprisingly, the fruits were also found to contain guttiferones I, J, and K, compounds never reported in G. cambogia, along with three new compounds, namely, guttiferone M (1), guttiferone N (2), and the oxidized derivative of guttiferone K (6). Oxy-guttiferone K (6) is the first example of tetracyclic xanthone derived from the oxidation of a polyisoprenylated benzophenone from natural source. The natural formation of oxy-guttiferone K is in agreement with the previously described cyclization of garcinol by DPPH.