Self-organization of oriented calcium carbonate/polymer composites: Effects of a matrix peptide isolated from the exoskeleton of a crayfish
Self-organization of oriented calcium carbonate/polymer composites: Effects of a matrix peptide isolated from the exoskeleton of a crayfish
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DOI：
10.1002/anie.200503800
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Kato, Takashi
中科院分区：
文献类型：
--
作者：
Sugawara, Ayae;Nishimura, Tatsuya;Kato, Takashi
生物矿物质是无机/有机复合材料，具有结构支撑、保护和矿物储存的作用。[1]蛋白质和多糖等生物大分子的协同作用在生物矿物质形成的形态控制中起着决定性作用。 [1]大量生物矿物成核和生长的体外实验表明，其形态受到提取的骨和牙本质、[2]软体动物壳、[3]骨骼、[4]海胆幼虫骨针[5]、海鞘骨针[6]和珊瑚藻骨骼[7]的有机生物大分子的影响。然而，由于这些生物大分子的分离和纯化困难，对单个蛋白质的研究受到限制。[3g]了解生物矿化单个蛋白质的结构-功能关系不仅可以更深入地了解生物矿化，而且可以为新型无机/有机复合材料的设计提供思路。[1a, 8]我们的策略是开发具有受控形态和性能的新型无机/有机复合材料。我们通过使用聚合物薄膜和更简单的酸性聚合物（例如聚丙烯酸和聚谷氨酸）的组合制备了薄膜 CaCO3 晶体。 [9]为了进一步控制此类复合材料的形态，必须对有机基质进行更仔细的设计。从材料科学的角度来看，甲壳类动物的外骨骼[10]是令人着迷的生物矿物，因为它们具有延展性、坚韧和轻质。小龙虾的外骨骼主要由α-甲壳素/蛋白质微纤维和与纤维紧密相连的碳酸钙骨架组成。图1a为扫描电子显微镜
Biological minerals are inorganic/organic composites that function as structural supports, protection, and mineral stores.[1] The cooperation of biomacromolecules such as proteins and polysaccharides plays a determining role in morphological control in the formation of biominerals.[1] A number of in vitro experiments for the nucleation and growth of biominerals demonstrated that their morphologies are influenced by the extracted organic biomacromolecules of bone and dentin,[2] mollusk shells,[3] skeletons,[4] and larval spicules [5] of sea urchin, ascidian spicules,[6] and coralline alga skeletons.[7] However, studies on individual proteins are limited because of difficulties in the isolation and purification of these biomacromolecules.[3g] An understanding of the structure–function relationships of individual proteins for biomineralization would offer not only deeper insight into biomineralization, but also ideas for the design of novel inorganic/organic composite materials.[1a, 8] Our strategy is to develop new inorganic/organic composites that exhibit controlled morphologies and properties. We have prepared thinfilm CaCO3 crystals by using a combination of polymer thin films and simpler acidic polymers such as poly (acrylic acid) and poly (glutamic acid).[9] For further control of the morphologies of such composite materials, more careful design of the organic matrix is essential.The exoskeletons of crustaceans [10] are fascinating biominerals in the view of materials science, because they are ductile, tough, and lightweight. The exoskeleton of crayfish mainly consists of frameworks of α-chitin/protein microfibrils and calcium carbonate that is closely associated with the fibrils. Figure1a shows the scanning electron microscopy