Nanotechnology in bladder cancer: current state of development and clinical practice.
Nanotechnology in bladder cancer: current state of development and clinical practice.
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DOI：
10.2217/nnm.14.212
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Pan CX
中科院分区：
文献类型：
--
作者：
Tomlinson B;Lin TY;Dall'Era M;Pan CX
Nanotechnology is being developed for the diagnosis and treatment of both nonmyoinvasive bladder cancer (NMIBC) and invasive bladder cancer. The diagnostic applications of nanotechnology in NMIBC mainly focus on tumor identification during endoscopy to increase complete resection of bladder cancer while nanotechnology to capture malignant cells or their components continues to be developed. The therapeutic applications of nanotechnology in NMIBC are to reformulate biological and cytotoxic agents for intravesical instillation, combine both diagnostic and therapeutic application in one nanoformulation. In invasive and advanced bladder cancer, magnetic resonance imaging with supraparamagnetic iron oxide nanoparticles can improve the sensitivity and specificity in detecting small metastasis to lymph nodes. Nanoformulation of cytotoxic agents can potentially decrease the toxicity while increasing efficacy.
