Treatment of ramsay hunt syndrome with acyclovir prednisone: Significance of early diagnosis and treatment
Treatment of ramsay hunt syndrome with acyclovir prednisone: Significance of early diagnosis and treatment
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DOI：
10.1002/ana.410410310
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发表时间：
1997-03-01
影响因子：
11.2
通讯作者：
Yanagihara, N
中科院分区：
文献类型：
--
作者：
Murakami, S;Hato, N;Yanagihara, N
尽管抗病毒药物阿昔洛韦目前用于治疗拉姆齐亨特综合征，但其对面神经和听力恢复的影响仍存在争议。我们回顾性分析了阿昔洛韦-泼尼松治疗 80 名 Ramsay Hunt 患者的效果。在 28 名面瘫发病 3 天内开始治疗的患者中，21 名（75%）完全康复。相比之下，在发病后 7 天以上开始治疗的 23 名患者中，只有 7 名（30%）面瘫完全康复。这些组之间的面神经恢复存在显着差异。通过神经兴奋性测试证明早期给予阿昔洛韦-泼尼松可以减少神经变性。早期治疗的患者听力恢复也往往更好。静脉注射和口服阿昔洛韦治疗之间的面神经结果没有显着差异。
Although the antiviral agent acyclovir is currently used for the treatment of Ramsay Hunt syndrome, its effects on facial nerve and hearing recovery remain controversial. We retrospectively analyzed the effects of acyclovir-prednisone treatment in 80 Ramsay Hunt patients. Of 28 patients for whom treatment was begun within 3 days of the onset of facial paralysis, the recovery from paralysis was complete in 21 (75%). By comparison, of 23 patients for whom treatment was begun more than 7 days after onset, recovery from facial paralysis was complete in only 7 (30%). A significant difference in facial nerve recovery was found between these groups. Early administration of acyclovir-prednisone was proved to reduce nerve degeneration by nerve excitability testing. Hearing recovery also tended to be better in patients with early treatment. There was no significant difference in facial nerve outcome between intravenous and oral acyclovir treatment.