Platelet-derived chemokines in inflammation and atherosclerosis
Platelet-derived chemokines in inflammation and atherosclerosis
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DOI：
10.1016/j.cyto.2017.09.013
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发表时间：
2019-10-01
期刊：
影响因子：
3.8
通讯作者：
Stellos, Konstantinos
中科院分区：
文献类型：
--
作者：
Bakogiannis, Constantinos;Sachse, Marco;Stellos, Konstantinos
血小板是炎性无核细胞，在动脉粥样硬化的发展和表现中具有公认的作用。活化的血小板分泌过多的趋化因子，包括CXCL 4或血小板因子4（PF 4）、CCL 5、CXCL 12或基质细胞衍生因子-1 α（SDF-1 α）、CXCL 16等，其在血管损伤部位引发或促进局部炎症过程。这些过程主要由循环造血干细胞、中性粒细胞、单核细胞或淋巴细胞在血管壁上的募集介导。在急性缺血条件下，血小板衍生的趋化因子可促进骨髓衍生的祖细胞的动员及其在病变部位的归巢。本文综述了血小板源性趋化因子在炎症和动脉粥样硬化中的作用。此外，我们还讨论了血浆趋化因子水平在动脉粥样硬化性心脏病预后中的临床价值。
Platelets are inflammatory anuclear cells with a well-established role in the development and manifestation of atherosclerosis. Activated platelets secrete a plethora of chemokines including CXCL4 or platelet factor 4 (PF4), CCL5, CXCL12 or stromal cell derived factor-1 alpha (SDF-1 alpha), CXCL16 and others, which initiate or promote local inflammatory processes at sites of vascular injury. These processes are mainly mediated by the recruitment of circulating haematopoietic stem cells, neutrophils, monocytes or lymphocytes on vascular wall. Under acute ischemic conditions platelet-derived chemokines may promote the mobilization of bone marrow-derived progenitor cells and their homing at lesion sites. This review focuses on the role of platelet-derived chemokines in inflammation and atherosclerosis. Further, we discuss the clinical value of plasma levels of chemokines in the prognosis of atherosclerotic heart disease.