Actin dynamics in protein homeostasis.
Actin dynamics in protein homeostasis.
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DOI：
10.1042/bsr20210848
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发表时间：
2022-09-30
影响因子：
4
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中科院分区：
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细胞内稳态在所有生物体中通过细胞成分和组织的不断调整来维持，以解释环境背景。微调蛋白质的最佳平衡，或蛋白质稳态，对维持细胞稳态至关重要。肌动蛋白是细胞骨架的主要组成部分，形成许多不同的结构，这些结构对细胞环境非常敏感。此外，肌动蛋白结构与涉及mRNA和蛋白质产生和降解以及蛋白质调节的多个因子相互作用，并且对于所述多个因子的功能和调节至关重要。总而言之，肌动蛋白是一个关键的，如果经常被忽视，调节蛋白质稳态在真核生物。在这篇综述中，我们强调了这些作用，以及它们是如何改变细胞应激，从mRNA转录到蛋白质降解。
Cell homeostasis is maintained in all organisms by the constant adjustment of cell constituents and organisation to account for environmental context. Fine-tuning of the optimal balance of proteins for the conditions, or protein homeostasis, is critical to maintaining cell homeostasis. Actin, a major constituent of the cytoskeleton, forms many different structures which are acutely sensitive to the cell environment. Furthermore, actin structures interact with and are critically important for the function and regulation of multiple factors involved with mRNA and protein production and degradation, and protein regulation. Altogether, actin is a key, if often overlooked, regulator of protein homeostasis across eukaryotes. In this review, we highlight these roles and how they are altered following cell stress, from mRNA transcription to protein degradation.