A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning
A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning
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DOI：
10.1101/lm.92305
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发表时间：
2005-07-01
影响因子：
2
通讯作者：
Jaffard, R
中科院分区：
文献类型：
--
作者：
Calandreau, L;Desmedt, A;Jaffard, R
收敛数据表明，外侧（LA）和基底外侧（BLA）杏仁核在恐惧调节中的分离作用，取决于是否考虑离散条件刺激（CS）-无条件刺激（US）或情境-US关联。在这里，我们发现 BLA 的预训练失活选择性地损害了对环境的调节。相比之下，LA 的失活会破坏对离散音 CS 的调节，但也会削弱或增强上下文调节，具体取决于上下文是在前景还是在背景。因此，这些发现完善了当前杏仁核在情绪学习中的功能模型，表明 BLA 和 LA 不仅对基本关联和情境美国关联有不同的贡献，而且还通过它们的相互作用促进这两种关联中最相关的关联。
Convergent data Suggest dissociated roles for the lateral (LA) and basolateral (BLA) amygdaloid nuclei in fear conditioning, depending oil whether a discrete conditioned Stimulus (CS)-unconditional stimulus (US) or context-US association is considered. Here, we show that pretraining inactivation of the BLA selectively impaired conditioning to context. In contrast, inactivation of the LA disrupted conditioning to the discrete tone CS, but also either impaired or enhanced contextual conditioning, depending oil whether the context was in the foreground or in the background. Hence, these findings refine the Current model of the amygdala function in emotional learning by showing that the BLA and the LA not only differentially contribute to elemental and context-US association, but also promote, through their interaction, the most relevant of these two associations.