Serum Aldosterone Is Associated with Inflammation and Aortic Stiffness in Normotensive Overweight and Obese Young Adults
Serum Aldosterone Is Associated with Inflammation and Aortic Stiffness in Normotensive Overweight and Obese Young Adults
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DOI：
10.3109/10641963.2011.618200
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发表时间：
2012-01-01
影响因子：
12.3
通讯作者：
Sutton-Tyrrell, Kim
中科院分区：
文献类型：
--
作者：
Cooper, Jennifer N.;Tepper, Ping;Sutton-Tyrrell, Kim
肥胖者的循环醛固酮会增加，并且与高血压和老年人的动脉硬化有关。本文的目的是确定 20-45 岁血压正常的超重和肥胖成年人 (n = 344) 中血清醛固酮是否与脉搏波速度 (PWV)（动脉僵硬度的测量指标）相关。测量心脏-股骨、股骨-踝和臂-踝PWV。样本中 77% 为女性，平均体重指数为 32.9 kg/m(2) (SD 3.9)，中位血清醛固酮为 106.5 pg/mL（四分位距 79.9, 155.5），平均 24 小时尿钠排泄量为 185.9 mEq/天（SD 69.6）。在双变量分析中，较高的血清醛固酮与任何 PWV 测量值均不显着相关。然而，在多元线性回归中，调整年龄、性别、种族、身高、心率、平均动脉压和腰围后，较高的醛固酮对数与较高的对数心脏-股动脉 PWV 相关（β(se) = 0.042(0.021)，P = .049）。调整 C 反应蛋白后，这种关联不再显着（β(se) = 0.035(0.021)，P = .10）。循环醛固酮可能在血压正常的超重和肥胖成人的血管炎症和主动脉硬化中发挥重要作用。
Circulating aldosterone is increased in obesity and is associated with arterial stiffening in hypertensives and older adults. The aim of this article was to determine whether serum aldosterone is associated with pulse wave velocity (PWV), a measure of arterial stiffness, in normotensive overweight and obese adults aged 20-45 years (n = 344). Heart-femoral, femoral-ankle, and brachial-ankle PWV were measured. The sample was 77% female with mean body mass index 32.9 kg/m(2) (SD 3.9), median serum aldosterone 106.5 pg/mL (interquartile range 79.9, 155.5), and mean 24-hour urinary sodium excretion 185.9 mEq/day (SD 69.6). Higher serum aldosterone was not significantly correlated with any PWV measure in bivariate analysis. However, in multiple linear regression, adjusting for age, sex, race, height, heart rate, mean arterial pressure, and waist circumference, higher log aldosterone was associated with greater log heart-femoral PWV (beta(se) = 0.042(0.021), P = .049). After adjusting for C-reactive protein, this association was no longer significant (beta(se) = 0.035(0.021), P = .10). Circulating aldosterone may play an important role in vascular inflammation and aortic stiffening in normotensive overweight and obese adults.