Thyroid autoimmunity, depression and anxiety; are there any connections? An epidemiological study of a large population
Thyroid autoimmunity, depression and anxiety; are there any connections? An epidemiological study of a large population
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DOI：
10.1016/j.jpychores.2005.04.002
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发表时间：
2005-11-01
影响因子：
4.7
通讯作者：
Dahl, AA
中科院分区：
文献类型：
--
作者：
Engum, A;Bjoro, T;Dahl, AA
目的：本研究的目的是在大量人群中研究抗甲状腺抗体、抑郁和焦虑之间的关系。方法：在30,175名年龄在40-84岁的人群中，对所有女性和50%的男性进行促甲状腺激素(TSH)检测。检测了几乎所有TSH和GT=4.0mU/L(n=1700)和随机选择的无甲状腺疾病或生化异常的样本(n=745)的甲状腺过氧化物酶自身抗体。采用医院焦虑抑郁量表(HADS)对患者进行焦虑和抑郁水平筛查。采用多因素Logistic回归分析方法对相关因素进行分析。结果：在TSH正常且无已知甲状腺疾病的个体中，TPOAb的患病率女性为14.2%，男性为4.3%。生化甲状腺功能异常人群中TPOAb的患病率女性为59.0%，男性为38.9%。没有发现甲状腺自身免疫与抑郁或焦虑之间存在关联，也没有根据年龄、性别、促甲状腺激素和甲状腺激素(T-4)进行粗略调整。结论：甲状腺自身免疫性疾病是人群中常见的疾病，主要影响女性。在一项以人群为基础的研究中，没有发现抗甲状腺抗体与抑郁或焦虑之间的联系。(C)2005 Elsevier Inc.保留所有权利。
Objective: The aim of the study was to examine the relationship between antithyroid antibodies, depression, and anxiety in a large population. Methods: In a population of 30,175 individuals aged 40-84 years, thyroid-stimulating hormone (TSH) was assessed in all women and in 50% of the men. Thyroid peroxidase autoantibodies (TPOAb) were measured in almost all samples with TSH >= 4.0 mU/L (n = 1700) and in randomly selected samples without thyroid disease or biochemical dysfunction (n = 745). The levels of anxiety and depression were screened using the Hospital Anxiety and Depression Scale (HADS). Relations were investigated with multiple logistic regression analyses. Results: In individuals with normal TSH and without known thyroid disorder, the prevalence of TPOAb was 14.2% in women and 4.3% in men. The prevalence of TPOAb in participants with biochemical thyroid dysfunction was 59.0% in women and 38.9% in men. No associations were found between thyroid autoimmunity and depression or anxiety, neither crude nor adjusted for age, gender, TSH, and thyroxine (T-4). Conclusion: Thyroid autoimmunity is a common disorder in the population, mainly affecting females. In a population-based study, no associations were found between antithyroid antibodies and depression or anxiety. (c) 2005 Elsevier Inc. All rights reserved.