Ocular rigidity in living human eyes
Ocular rigidity in living human eyes
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DOI：
10.1167/iovs.04-0162
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发表时间：
2005-02-01
影响因子：
4.4
通讯作者：
Tsilimbaris, MK
中科院分区：
文献类型：
--
作者：
Pallikaris, IG;Kymionis, GD;Tsilimbaris, MK
目的.测量大量受试者在临床上遇到的眼内压（IOP）下的眼硬度系数，并检查眼硬度与其他因素的可能相关性，如患者的年龄、眼部参数（眼轴长度和角膜厚度）以及影响眼睛的病理条件。通过将200穆尔盐溶液（以4.5穆尔为步长）通过利姆布斯注射到前房中，同时用传感器连续监测IOP，直到60 mm Hg的极限，在经历白内障手术的79只眼睛中测定压力-体积关系和眼硬度系数（K）。在10至35 mm Hg的IOP范围内的数据用于计算巩膜刚度系数。所有测量均在一天中的同一时间进行，以消除任何可能的昼夜变化。结果。平均眼强直系数为0.0126 mm Hg/穆尔（95%置信区间[CI]，0.0112 - 0.0149）。刚性系数与患者年龄之间存在统计学显著正相关（P = 0.02），而检查的眼部参数（眼轴长度，P = 0.09;角膜厚度，P = 0.12）未观察到类似结果。糖尿病（P = 0.39）、老年性黄斑变性（P = 0.55）和高血压（P = 0.45）患者的相关性未发现。本研究提供了定量数据的基础上，在一个大系列的活体人眼测量的眼硬度系数。眼强直系数与患者年龄呈正相关。
PURPOSE. To measure the rigidity coefficient of a large number of subjects at clinically encountered intraocular pressures (IOPs) and to examine the possible correlation of ocular rigidity with other factors, such as the age of the patients, ocular parameters ( axial length and corneal thickness), and pathologic conditions affecting the eye.METHODS. The pressure - volume relationship and the ocular rigidity coefficient ( K) were determined in 79 eyes undergoing cataract surgery, by injecting 200 muL of saline solution ( in steps of 4.5 muL) through the limbus into the anterior chamber, while continually monitoring the IOP with a transducer, up to the limit of 60 mm Hg. Data within an IOP range of 10 to 35 mm Hg were used to calculate the scleral rigidity coefficient. All measurements were taken at the same time of day, to eliminate any possible diurnal variation.RESULTS. The mean ocular rigidity coefficient was 0.0126 mm Hg/muL (95% confidence interval [CI], 0.0112 - 0.0149). A statistically significant positive correlation between the rigidity coefficient and age of the patient was found ( P = 0.02), whereas similar findings were not observed for the examined ocular parameters ( axial length, P = 0.09; and corneal thickness, P = 0.12). No correlation was found for patients with diabetes mellitus ( P = 0.39), age-related macular degeneration ( P = 0.55), and hypertension ( P = 0.45).CONCLUSIONS. The present study provides quantitative data on the ocular rigidity coefficient based on measurements in a large series of living human eyes. A positive correlation between the ocular rigidity coefficient and the patient's age was documented.