Prevention by Catatoxic Steroids of Lithocholic Acid-Induced Biliary Concrements in the Rat 1
Prevention by Catatoxic Steroids of Lithocholic Acid-Induced Biliary Concrements in the Rat 1
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通过催化毒性类固醇预防石胆酸诱导的大鼠胆汁结石 1
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
H. Selye
中科院分区：
文献类型：
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作者：
H. Selye
对大鼠的实验表明，石胆酸诱导的肝脏和胆总管变化以及相关的胆汁结石形成、黄疸、体重减轻和死亡率均被某些紧张性类固醇（PCN和CS-1）以及甲状腺素和三碘甲状腺原氨酸抑制或消除。泼尼松龙和曲安西龙有相反的效果。在经典的肝微粒体酶诱导剂中，二苯基海因是无效的，苯巴比妥在影响石胆酸毒性方面的效力远低于PCN或CS-1。作者感谢材料和方法部分列出的公司捐赠了本实验中使用的化合物。
Summary Experiments on rats indicate that lithocholic acid-induced changes in the liver and choledochus, as well as the associated bile concrement formation, icterus, loss of body weight and mortality, are all inhibited or abolished by certain catatoxic steroids (PCN and CS-1) as well as by thyroxine and triiodothyronine. Prednisolone and triamcinolone have an opposite effect. Among the classic hepatic microsomal enzyme inducers, diphenylhydantoin is ineffective, and phenobarbital is much less potent than PCN or CS-1 in influencing the toxicity of lithocholic acid. The author thanks the Companies listed in the Materials and Methods section for kindly donating the compounds used in this experiment.