Small-animal whole-body photoacoustic tomography: a review.
Small-animal whole-body photoacoustic tomography: a review.
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DOI：
10.1109/tbme.2013.2283507
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Wang LV
中科院分区：
文献类型：
--
作者：
Xia J;Wang LV
随着小动物在生物医学研究中的广泛应用，活体小动物全身成像技术发挥着越来越重要的作用。光声断层成像（PAT）是一种新兴的全身成像模式，显示出巨大的潜力，为临床前研究。作为一种混合技术，PAT基于对内源性组织发色团（如氧合血红蛋白和脱氧血红蛋白）或外源性造影剂的光吸收的声学检测。由于超声在组织中的散射比光少得多，PAT在光学弹道和扩散机制中生成高分辨率图像。使用血液吸收相对较低的近红外光，PAT可以以声学定义的空间分辨率通过小动物的整个身体成像。解剖结构和血管结构的成像与内源性血红蛋白对比，而功能和分子图像是由外源性光学对比的广泛选择。本文回顾了快速增长的小动物全身PAT领域，并强调了在过去十年中所做的研究。
With the wide use of small animals for biomedical studies, in vivo small-animal whole-body imaging plays an increasingly important role. Photoacoustic tomography (PAT) is an emerging whole-body imaging modality that shows great potential for preclinical research. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous tissue chromophores, such as oxy-hemoglobin and deoxy-hemoglobin, or exogenous contrast agents. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Using near-infrared light, which has relatively low blood absorption, PAT can image through the whole body of small animals with acoustically defined spatial resolution. Anatomical and vascular structures are imaged with endogenous hemoglobin contrast, while functional and molecular images are enabled by the wide choice of exogenous optical contrasts. This paper reviews the rapidly growing field of small-animal whole-body PAT and highlights studies done in the past decade.