Fusiform Gyrus Dysfunction is Associated with Perceptual Processing Efficiency to Emotional Faces in Adolescent Depression: A Model-Based Approach.
Fusiform Gyrus Dysfunction is Associated with Perceptual Processing Efficiency to Emotional Faces in Adolescent Depression: A Model-Based Approach.
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DOI：
10.3389/fpsyg.2016.00040
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发表时间：
2016
影响因子：
3.8
通讯作者：
Yang TT
中科院分区：
文献类型：
--
作者：
Ho TC;Zhang S;Sacchet MD;Weng H;Connolly CG;Henje Blom E;Han LK;Mobayed NO;Yang TT
虽然现存的文献集中于重度抑郁症（MDD），其特征在于处理情感刺激的异常（例如，面部表情），关于认知的哪些特定方面影响情感刺激的评价以及潜在的神经相关性是什么，知之甚少。为了研究这些问题，我们评估了26名诊断为MDD的青少年和37名匹配良好的健康对照（HCL），他们在功能性磁共振成像（fMRI）期间完成了动态变形面孔的情感识别任务。我们分析了行为数据，使用响应时间（RT）的顺序抽样模型，通常用于阐明认知方面的二元知觉决策任务：线性弹道累加器（LBA）模型。使用分层贝叶斯估计方法，我们获得了面部情绪识别任务的LBA参数的群体水平和个人水平的估计。虽然MDD和HCL组在平均RT、准确性或感知处理效率的组水平估计方面没有差异（即，LBA的漂移率参数），在面部情绪识别任务期间，与HCL组相比，MDD组在左梭状回中显示出显著降低的反应。此外，在抑郁症组，在左侧梭状回的fMRI信号在情感面孔处理显着相关的更大的个人水平的估计知觉处理效率。因此，我们的研究结果表明，情感加工偏差在青少年与抑郁症的特点是更大的知觉加工效率的情感视觉信息的感觉脑区负责早期处理的视觉信息。讨论了我们结果的理论、方法和临床意义。
While the extant literature has focused on major depressive disorder (MDD) as being characterized by abnormalities in processing affective stimuli (e.g., facial expressions), little is known regarding which specific aspects of cognition influence the evaluation of affective stimuli, and what are the underlying neural correlates. To investigate these issues, we assessed 26 adolescents diagnosed with MDD and 37 well-matched healthy controls (HCL) who completed an emotion identification task of dynamically morphing faces during functional magnetic resonance imaging (fMRI). We analyzed the behavioral data using a sequential sampling model of response time (RT) commonly used to elucidate aspects of cognition in binary perceptual decision making tasks: the Linear Ballistic Accumulator (LBA) model. Using a hierarchical Bayesian estimation method, we obtained group-level and individual-level estimates of LBA parameters on the facial emotion identification task. While the MDD and HCL groups did not differ in mean RT, accuracy, or group-level estimates of perceptual processing efficiency (i.e., drift rate parameter of the LBA), the MDD group showed significantly reduced responses in left fusiform gyrus compared to the HCL group during the facial emotion identification task. Furthermore, within the MDD group, fMRI signal in the left fusiform gyrus during affective face processing was significantly associated with greater individual-level estimates of perceptual processing efficiency. Our results therefore suggest that affective processing biases in adolescents with MDD are characterized by greater perceptual processing efficiency of affective visual information in sensory brain regions responsible for the early processing of visual information. The theoretical, methodological, and clinical implications of our results are discussed.