Neural mechanisms underlying the temporal control of sequential saccade planning in the frontal eye field.
Neural mechanisms underlying the temporal control of sequential saccade planning in the frontal eye field.
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额叶视野中顺序扫视计划的时间控制的神经机制。
DOI：
10.1073/pnas.2108922118
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发表时间：
2021
影响因子：
11.1
通讯作者：
Murthy,Aditya
中科院分区：
文献类型：
--
作者：
Basu,Debaleena;Sendhilnathan,Naveen;Murthy,Aditya
眼球跳动的序列在我们的视觉环境中起着重要的作用。虽然神经活动已被证明在单次扫视之前会上升到一个阈值，但多次扫视的神经基础尚不清楚。为了了解眼跳序列的神经控制，我们记录了猕猴在执行顺序眼跳任务时的前额眼场(FEF)。我们发现，两个扫视计划的并行规划会带来处理瓶颈，特别是通过降低与扫视相关的斜坡活动的增长率和提高门槛。频率中断影响了两个眼跳计划，以及一个计算模型，其中与两个眼跳计划相关的活动相互不对称地相互抑制，预测了实验观察到的行为和神经结果。借鉴心理学中的模型，我们的结果证明了一种处理瓶颈的能力共享机制，即序列中的多个扫视计划通过与扫视相关的斜坡活动的扰动来竞争处理能力。最后，我们发现，与运动相关神经元相比，FEF神经元中的视觉活动不受多个眼跳目标的存在的影响，这表明，对于知觉简单的任务，运动相关神经元内的抑制主要实例化能力共享。综上所述，我们展示了如何将受心理学启发的能力共享模型映射到神经反应上，以了解快速眼跳序列的控制。
Sequences of saccadic eye movements are instrumental in navigating our visual environment. While neural activity has been shown to ramp up to a threshold before single saccades, the neural underpinnings of multiple saccades is unknown. To understand the neural control of saccade sequences, we recorded from the frontal eye field (FEF) of macaque monkeys while they performed a sequential saccade task. We show that the concurrent planning of two saccade plans brings forth processing bottlenecks, specifically by decreasing the growth rate and increasing the threshold of saccade-related ramping activity. The rate disruption affected both saccade plans, and a computational model, wherein activity related to the two saccade plans mutually and asymmetrically inhibited each other, predicted the behavioral and neural results observed experimentally. Borrowing from models in psychology, our results demonstrate a capacity-sharing mechanism of processing bottlenecks, wherein multiple saccade plans in a sequence compete for the processing capacity by the perturbation of the saccade-related ramping activity. Finally, we show that, in contrast to movement-related neurons, visual activity in FEF neurons is not affected by the presence of multiple saccade targets, indicating that, for perceptually simple tasks, inhibition within movement-related neurons mainly instantiates capacity sharing. Taken together, we show how psychology-inspired models of capacity sharing can be mapped onto neural responses to understand the control of rapid saccade sequences.