Blood dendritic cell levels and phenotypic characteristics in relation to etiology of end-stage heart failure: Implications for dilated cardiomyopathy
Blood dendritic cell levels and phenotypic characteristics in relation to etiology of end-stage heart failure: Implications for dilated cardiomyopathy
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DOI：
10.1016/j.ijcard.2007.10.031
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发表时间：
2009-01-09
影响因子：
3.5
通讯作者：
Bogers, Ad J. J. C.
中科院分区：
文献类型：
--
作者：
Athanassopoulos, Petros;Balk, Aggie H. M. M.;Bogers, Ad J. J. C.
背景：树突状细胞（DC）介导的对自身抗原的免疫反应失调被认为是维持实验性心力衰竭（HF）的一个重要特征。为了评估血液dc在不同来源的心肌病中的作用，我们根据人类HF的严重程度和病因检查了髓细胞（mDC）和浆细胞样（pDC）亚群水平和成熟特征。方法：采用四色全血流式细胞术对12例纽约心脏协会（NYHA）ⅱ类、28例NYHAⅲ~ⅳ类HF患者和18例健康对照进行mDCs和pDCs绝对数量的研究。结果：终末期（NYHA III-IV） HF患者的循环DC亚群水平与NYHA ii患者和对照组相当。然而，在NYHA III-IV组中，非缺血性扩张型心肌病（DCM）患者的总DC水平较高(P
Background: Dysregulation of dendritic cell (DC) mediated immune responses towards auto-antigens, is considered an important feature in the maintenance of experimentally induced heart failure (HF). In order to evaluate the role of blood DCs in cardiomyopathies of different origins, we examined myeloid (mDC) and plasmacytoid (pDC) subset levels and maturation characteristics, according to HF severity and etiology in humans.Methods: Absolute numbers of mDCs and pDCs in 12 New York Heart Association (NYHA) class-II, 28 NYHA class III-IV HF patients and 18 healthy controls, were studied by 4-colour whole blood flow cytometry.Results: End-stage (NYHA III-IV) HF patients had comparable circulating DC subset levels to NYHA-II patients and controls. However, within the NYHA III-IV group total DC levels in patients with non-ischemic dilated cardiomyopathy (DCM) were higher (P