Single-Particle Cryo-Electron Microscopy: Mathematical Theory, Computational Challenges, and Opportunities
Single-Particle Cryo-Electron Microscopy: Mathematical Theory, Computational Challenges, and Opportunities
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DOI：
10.1109/msp.2019.2957822
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发表时间：
2020-03-01
影响因子：
14.9
通讯作者：
Singer, Amit
中科院分区：
文献类型：
--
作者：
Bendory, Tamir;Bartesaghi, Alberto;Singer, Amit
近年来，利用冷冻电子显微镜（cryo-EM）阐明了大量新的分子结构，这主要归功于硬件技术和数据处理技术的进步。由于这些令人兴奋的新发展，冷冻电镜被《自然方法》评选为“2015 年度方法”，2017 年诺贝尔化学奖授予了冷冻电镜领域的三位先驱者：Jacques Dubochet、Joachim Frank 和 Richard Henderson，“表彰他们开发了冷冻电子显微镜，用于溶液中生物分子的高分辨率结构测定”[93]。
In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these exciting new developments, cryo-EM was selected by Nature Methods as the "Method of the Year 2015," and the Nobel Prize in Chemistry 2017 was awarded to three pioneers in the cryo-EM field: Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution" [93].