Additive Prognostic Value of Left Ventricular Systolic Dysfunction in a Population-Based Cohort
Additive Prognostic Value of Left Ventricular Systolic Dysfunction in a Population-Based Cohort
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DOI：
10.1161/circimaging.116.004661
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发表时间：
2016-07-01
影响因子：
7.5
通讯作者：
Staessen, Jan A.
中科院分区：
文献类型：
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作者：
Kuznetsova, Tatiana;Cauwenberghs, Nicholas;Staessen, Jan A.
背景-二维斑点跟踪技术能够测量心脏收缩期间的心肌变形（应变）。最近的临床研究探讨了左心室整体纵向应变（GLS）的预后作用。然而，社区中关于心血管结局与GLS之间关系的数据很少。因此，我们假设，GLS包含添加剂的预后信息超过和超越传统的心血管危险因素在一个大的，以人口为基础的cohol.Methods和Results-We测量GLS的二维斑点跟踪心尖4腔视图中的791名参与者（平均年龄50.9岁）。我们计算了中壁、心内膜和心外膜GLS的多变量校正风险比，同时考虑了家族聚集性和心血管危险因素。中位随访时间为7.9年（第5 - 95百分位数，3.7-9.6）。在连续分析中，应用协变量校正，中壁、内膜和心外膜GLS是致命性和非致命性心血管疾病的重要预测因子（n=96; P
Background-Techniques of 2-dimensional speckle tracking enable the measurement of myocardial deformation (strain) during systole. Recent clinical studies explored the prognostic role of left ventricular global longitudinal strain (GLS). However, there are few data on the association between cardiovascular outcome and GLS in the community. Therefore, we hypothesized that GLS contains additive prognostic information over and beyond traditional cardiovascular risk factors in a large, population-based cohort.Methods and Results-We measured GLS by 2-dimensional speckle tracking in the apical 4-chamber view in 791 participants (mean age 50.9 years). We calculated multivariable adjusted hazard ratios for midwall, endocardial, and epicardial GLS, while accounting for family cluster and cardiovascular risk factors. Median follow-up was 7.9 years (5th to 95th percentile, 3.7-9.6). In continuous analysis, with adjustments applied for covariables, midwall, endocardial, and epicardial GLS were significant predictors of fatal and nonfatal cardiovascular (n=96; P