Synthesis of 4-formyl-4-imidazolin-2-one nucleosides, isomers of uridine and 2'-deoxyuridine.
Synthesis of 4-formyl-4-imidazolin-2-one nucleosides, isomers of uridine and 2'-deoxyuridine.
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4-甲酰基-4-咪唑啉-2-酮核苷、尿苷和2-脱氧尿苷异构体的合成。
DOI：
10.1081/ncn-120027837
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Kalman,ThomasI
中科院分区：
文献类型：
--
作者：
Jiang,Xiang-Jun;Kalman,ThomasI
4 -甲酰基- 4 -咪唑啉- 2 - 1的核糖核苷衍生物和脱氧核糖核苷衍生物分别是尿苷和2 ' -脱氧尿苷的等构异构体，通过相应的5 -溴嘧啶核苷的环收缩，然后将产物的羧基侧链转化为各自的甲醛衍生物。
The syntheses of the ribo‐ and deoxyribonucleoside derivatives of 4‐formyl‐4‐imidazolin‐2‐one, isosteric isomers of uridine and 2′‐deoxyuridine, respectively, were carried out by ring contraction of the corresponding 5‐bromouracil nucleosides, followed by conversion of the carboxyl side‐chain of the products to the respective carboxaldehyde derivatives.