Seroprevalence of measles, mumps and rubella antibodies in Luxembourg: results from a national cross-sectional study
Seroprevalence of measles, mumps and rubella antibodies in Luxembourg: results from a national cross-sectional study
复制标题
DOI：
10.1017/s0950268803001584
复制
发表时间：
2004-01-01
影响因子：
4.2
通讯作者：
Schneider, F
中科院分区：
文献类型：
--
作者：
Mossong, J;Putz, L;Schneider, F
2000-2001年期间在卢森堡进行了一项血清流行率调查，以确定卢森堡人口对疫苗可预防感染的抗体状况。在随机选择的学校前瞻性地收集儿童和青少年的血液样本。成人样本是通过国家卫生实验室或强制性婚前检查的志愿患者获得的。麻疹，腮腺炎和风疹（MMR）病毒抗体浓度测定使用商业ELISA测试。麻疹、流行性腮腺炎和风疹病毒抗体标准化阳性率分别为96.58%、75.40%和95.69%。所有三种感染均观察到血清学的显著年龄依赖性，在引入MMR疫苗后出生的研究参与者在儿童期接种疫苗后抗体逐渐下降。年龄较大的研究参与者更有可能具有来自自然感染的抗体，其滴度始终高于年轻人。目前MMR疫苗接种覆盖率似乎足以预防麻疹和风疹的大规模局部暴发，但可能不足以预防腮腺炎。
A serololoical prevalence survey was carried Out in Luxembourg during 2000-2001 to determine the antibody status of the Luxembourg population against vaccine-preventable infections. Blood samples of children and adolescents were collected prospectively in randomly selected schools. Samples of adults were obtained through volunteer patients of the national health laboratory or of the mandatory pre-nuptial test. Measles, mumps and rubella (MMR) Virus antibody concentrations were measured using commercial ELISA tests. Age-standardized prevalence of measles, mumps and rubella virus antibodies was found to be 96.58, 75.40 and 95.69% respectively. Significant age-dependence of serology was observed for all three infections, with Study participants born after the introduction of the MMR vaccine experiencing a gradual decline of antibodies following vaccination in childhood. Older Study participants who were more likely to have antibodies from natural infection had consistently higher titres than younger individuals. Present vaccination coverage with MMR appears to be sufficient to prevent large local outbreaks of measles and rubella, but probably not mumps.