Brain targeting through the autonomous nervous system:: lessons from prion diseases
Brain targeting through the autonomous nervous system:: lessons from prion diseases
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DOI：
10.1016/j.molmed.2004.01.008
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发表时间：
2004-03-01
影响因子：
13.6
通讯作者：
Hauw, JJ
中科院分区：
文献类型：
--
作者：
Haïk, S;Faucheux, BA;Hauw, JJ
人类中枢神经系统(CNS)是各种病原体的靶标，这些病原体使用不同的途径绕过血脑屏障，例如通过感染的血细胞进入大脑，或者通过感觉或运动纤维进行逆行轴突运输。Prion是一种可传播的物质，当它们成功到达中枢神经系统时，会导致毁灭性的亚急性神经变性。最近两项集中于Pron神经侵袭途径的研究提供了一致的证据，表明在外周传播的情况下，例如人类消耗受污染的组织，感染因子通过交感去甲肾上腺素能神经元在淋巴组织中早期复制后到达中枢神经系统。
The human central nervous system (CNS) is targeted by diverse pathogens that use distinct pathways to bypass the blood-brain barrier, such as trafficking into the brain via infected blood cells or using retrograde axonal transport through sensory or motor fibers. Prions are transmissible agents that induce a devastating sub-acute neurodegeneration when they successfully reach the CNS. Two recent studies focusing on pathways of prion neuroinvasion provide converging evidence that, in the case of peripheral transmission, such as human consumption of contaminated tissue, the infectious agent uses the sympathetic noradrenergic neurons to reach the CNS after early replication in lymphoid tissues.