INHIBITION OF CELLULAR PROLIFERATION BY ANTISENSE OLIGODEOXYNUCLEOTIDES TO PCNA CYCLIN
INHIBITION OF CELLULAR PROLIFERATION BY ANTISENSE OLIGODEOXYNUCLEOTIDES TO PCNA CYCLIN
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DOI：
10.1126/science.2897717
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发表时间：
1988-06-10
期刊：
影响因子：
56.9
通讯作者：
BASERGA, R
中科院分区：
文献类型：
--
作者：
JASKULSKI, D;DERIEL, JK;BASERGA, R
增殖细胞核抗原（PCNA或细胞周期蛋白）是最近鉴定为DNA聚合酶δ的辅因子的核蛋白。当指数生长的Balb/c3 T3细胞暴露于PCNA的反义寡核苷酸时，DNA合成和有丝分裂都被完全抑制。相应的正义寡核苷酸没有抑制作用。这些实验表明PCNA（细胞周期蛋白）在细胞DNA合成和细胞周期进程中是重要的。
The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase .delta.. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression.