Apigenin: a promising molecule for cancer prevention.

Apigenin: a promising molecule for cancer prevention.
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DOI:
10.1007/s11095-010-0089-7
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发表时间:
2010-06
影响因子:
3.7
通讯作者:
Gupta, Sanjay
Gupta, Sanjay
中科院分区:
医学3区
文献类型:
--
作者:
Shukla, Sanjeev;Gupta, Sanjay

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芹菜素是一种天然存在的植物黄酮,大量存在于常见的水果和蔬菜中,被认为是一种具有抗炎、抗氧化和抗癌特性的生物活性类黄酮。流行病学研究表明,富含黄酮的饮食与降低某些癌症的风险有关,尤其是乳腺癌、消化道癌、皮肤癌、前列腺癌和某些血液系统恶性肿瘤。有研究表明,芹菜素可能对其他受氧化过程影响的疾病有保护作用,如心血管和神经系统疾病,尽管在这方面还需要进行更多的研究。虽然芹菜素作为一种癌症化学预防剂有很大的潜力,但还没有进行人体临床试验来检验补充芹菜素对疾病预防的影响。
Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properties. Epidemiologic studies suggest that a diet rich in flavones is related to a decreased risk of certain cancers, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies. It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard. Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent.
DOI: 10.1093/jn/134.5.1013
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影响因子: 4.2
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