THE EFFECT OF CHANGES IN BODY WEIGHT ON ATHEROSCLEROSIS IN THE RABBIT
THE EFFECT OF CHANGES IN BODY WEIGHT ON ATHEROSCLEROSIS IN THE RABBIT
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DOI：
10.1126/science.111.2872.31
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发表时间：
1950-01-01
期刊：
影响因子：
56.9
通讯作者：
FIRSTBROOK, JB
中科院分区：
文献类型：
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作者：
FIRSTBROOK, JB
动脉粥样硬化与肥胖的显着临床关联引发了一项关于减少热量摄入对实验诱发的兔子动脉粥样硬化严重程度影响的研究。根据体重将28只兔子分成对或每组3只；在整个实验过程中，每组中的一只动物随意进食 Purina Chow 饮食，这对动物中的另一只动物只允许自由进食动物前一天食物摄入量的 50%，而 3 组中的另外 2 只动物分别允许摄入 40% 和 60% 的食物。 2周后。在此方案中，所有兔子均服用 1 克。每天通过胃管收集悬浮胆固醇，持续 30 至 51 天。测定血液胆固醇水平。在开始胆固醇管理之前。行政期间每周一次。采用胆固醇方案4-7周后，处死动物；取出完整的主动脉，固定在 10% 福尔马林中，用苏丹 IV 染色，并根据 detd 的症状严重程度进行分级。通过病变涉及的主动脉内膜区域。统计分析显示食物摄入量与最终重量与初始重量之比之间存在高度显着的相关性。动脉粥样硬化程度与初始体重、体重无显着相关性。改变或胆固醇治疗的持续时间；与平均值的相关性血液胆固醇水平在 5% 水平时显着 (r = 0.43)。系数。动脉粥样硬化程度 (Y) 与总胆固醇剂量 (1) 的多重相关性，平均值。血液胆固醇水平 (2)，初始重量(3)、最终重量与初始重量之比。 (4) 显着性超过 1% 点 (rm= 0.7165)。标准偏回归系数。表明这些自变量在确定因变量估计值时的相对显着性如下：b''y1.234，0.150； b''y2.134 0.553； b''y3.124，0.484；和b''y4.123，0.535；因此 (2)、(3) 和 (4) 大约为同等重要。在评估怀疑引起动脉粥样硬化的药物时，必须进行实验。或体重变化的统计控制。
The striking clinical association of atherosclerosis with obesity has led to an investigation of the effect of decreased caloric intake on the severity of experimentally induced atherosclerosis in the rabbit. 28 rabbits were sorted into pairs or groups of 3 on the basis of body wt.; one animal of each group was given a Purina Chow diet ad libitum throughout the expt., the other member of the pair was allowed only 50% of the previous day''s food intake of the freely fed member, and the other 2 members of the groups of 3 were allowed 40 and 60%, respectively. After 2 wks. on this regimen all rabbits were given 1 g. of cholesterol in suspension daily by stomach tube for periods ranging from 30 to 51 days. Blood cholesterol level was detd. before the initiation of cholesterol admn. and weekly during the period of admn. After 4-7 weeks on the cholesterol regimen animals were sacrificed; the intact aortas were removed, fixed in 10% formalin, stained with Sudan IV, and graded as to the severity of symptoms as detd. by the area of the aortic intima involved by lesions. Statistical analysis showed a highly significant correlation between the food intake and ratio of final to initial wt. The degree of atherosclerosis was not significantly correlated with initial wt., wt. change, or the duration of cholesterol treatment; correlation with avg. blood cholesterol level was significant at the 5% level (r = 0.43). The coeff. of multiple correlation of the degree of atherosclerosis (Y) to total cholesterol dosage (1), avg. blood cholesterol level (2), initial wt. (3), and ratio of final to initial wt. (4) was significant beyond the 1% point (rm= 0.7165). Standard partial regression coeffs. indicating the relative significance of these independent variables in determining the estimated value of the dependent variable were as follows: b''y1.234, 0.150; b''y2.134 0.553; b''y3.124, 0.484; and b''y4.123, 0.535; thus (2), (3), and (4) are of approx. equal importance. In evaluation of agents suspected of causing atherosclerosis there must be exptl. or statistical control of changes in body wt.