Research opportunities in intraoperative radiation therapy: the next decade 2013-2023
Research opportunities in intraoperative radiation therapy: the next decade 2013-2023
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DOI：
10.1007/s12094-013-1019-z
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发表时间：
2013-09-01
影响因子：
3.4
通讯作者：
Ferrer, C.
中科院分区：
文献类型：
--
作者：
Calvo, F. A.;Sole, C. V.;Ferrer, C.
术中放射治疗（IORT）实践的现实是与有效和高精度的放射治疗技术相一致的，以安全地增加局部复发的风险区域。长期临床经验表明，包含iort的多模式方案似乎可以改善局部疾病控制，即使不能改善许多疾病的生存。IORT的研究是一个多学科的场景，涵盖了从辐射束适应发展到推进分子生物学结果的生物可预测性的知识。IORT过程中使用的技术参数是记录质量保证和临床结果分析的重要信息。此外，有专门针对IORT程序的治疗计划系统，以帮助治疗决策过程。报告系统地修订了IORT的研究和创新机会，包括辐射束调制、输送、剂量测定和规划；基础设施和处理因素；实验和临床放射生物学；临床试验，创新和转化研究发展。
The reality of intraoperative radiation therapy (IORT) practice is consistent with an efficient and highly precise radiation therapy technique to safely boost areas at risk for local recurrence. Long-term clinical experience has shown that IORT-containing multi-modality regimens appear to improve local disease control, if not survival in many diseases. Research with IORT is a multidisciplinary scenario that covers knowledge from radiation beam adapted development to advance molecular biology for bio-predictability of outcome. The technical parameters employed in IORT procedures are important information to be recorded for quality assurance and clinical results analysis. In addition, specific treatment planning systems for IORT procedures are available, to help in the treatment decision-making process. A systematic revision of opportunities for research and innovation in IORT is reported including radiation beam modulation, delivery, dosimetry and planning; infrastructure and treatment factors; experimental and clinical radiobiology; clinical trials, innovation and translational research development.