INVESTIGATION ON HYPERURICEMIA IN CHILDREN WITH OBESITY OR VARIOUS PEDIATRIC DISORDERS
INVESTIGATION ON HYPERURICEMIA IN CHILDREN WITH OBESITY OR VARIOUS PEDIATRIC DISORDERS
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DOI：
10.1080/15257770.2011.597370
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发表时间：
2011-01-01
影响因子：
1.3
通讯作者：
Tokuda, Masakuni
中科院分区：
文献类型：
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作者：
Kubota, Masaru;Nagai, Ayako;Tokuda, Masakuni
本研究旨在探讨高尿酸血症的频率和特点，在肥胖和生病的儿童。首先，我们建立了自己的血清尿酸（UA）参考值，因为UA值高度依赖于年龄。在对328个样本的分析中发现，UA的平均值随着年龄的增加而显著增加，这些样本包括< 1岁、1-3岁、4-6岁、7-9岁、10-12岁和13-15岁六个不同年龄组。仅在13-15岁年龄组中观察到显著的性别差异。高尿酸血症定义为每个年龄组的平均值加上2个标准差。接下来，我们检查了1,687名6-15岁肥胖儿童高尿酸血症的频率及其与代谢综合征（MetS）的关系。328名儿童（19.4%）出现高尿酸血症。其中98名（29.9%）患有met，而1359名无高尿酸血症的儿童中197名（14.5%）患有met。最后，对9405例患者的13675份样本进行了高尿酸血症发生率调查。排除冗余样本后，348例（3.7%）患者出现高尿酸血症。高尿酸血症患者男性多于女性。引起高尿酸血症的最常见疾病是胃肠炎，其次是呼吸道感染和心脏病。这是对儿童高尿酸血症的首次全面研究，有助于考虑其与成年期高尿酸血症和生活方式相关疾病的关系。
The present study aims at investigating the frequency and characteristics of hyperuricemia in both obese and sick children. First, we established our own reference values for serum uric acid (UA), since UA values are highly dependent upon age. In the analysis of 328 samples consisting of six different age groups: < 1, 1-3, 4-6, 7-9, 10-12, and 13-15 years, the mean values for UA were found to increase significantly with an increase of age. A significant sex difference was observed only in the age group of 13-15 years. Hyperuricemia was defined as the values over the mean value plus 2 standard deviations for each age group. Next, we examined the frequency of hyperuricemia in 1,687 obese children aged 6-15 years and its relation to metabolic syndrome (MetS). A total of 328 children (19.4%) were found to have hyperuricemia. Among them, 98 children (29.9%) had MetS, whereas 197 (14.5%) out of 1,359 children without hyperuricemia had MetS. Finally, the frequency of hyperuricemia in sick patients was investigated using 13,675 samples from 9,405 patients. Hyperuricemia was seen in 348 (3.7%) patients after excluding redundant samples. The number of patients with hyperuricemia was higher in males than in females. The most common disorder causing hyperuricemia was gastroenteritis, followed by respiratory tract infection and cardiac diseases. This first comprehensive study of childhood hyperuricemia is useful for considering its relationship with hyperuricemia and life-style-related disorders occurring in adulthood.