Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques
Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques
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DOI：
10.1038/emi.2012.31
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发表时间：
2012-10-01
影响因子：
13.2
通讯作者：
Jones-Engel, Lisa
中科院分区：
文献类型：
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作者：
Engel, Gregory A.;Wilbur, Alicia K.;Jones-Engel, Lisa
在这里，我们提出了一个案例系列从灵长类动物研究设施。指示病例是一只4岁的猪尾猕猴（Macaca nemestrina），实验性感染了嵌合型猿猴-人类免疫缺陷病毒（SHIVSF 162（P4）），体重减轻并被安乐死。根据尸检结果，该动物被诊断为猴艾滋病相关的机会性非典型分枝杆菌病（SAIDS）。随后，使用分子方法分析了来自指示动物的组织以及来自六名SHIV感染接触者的组织和口腔粘膜拭子，发现其含有结核分枝杆菌复合体（MTBC）特征性的核酸序列。这些数据表明，现有的方案不能可靠地检测用作实验模型的实验室灵长类动物中的MTBC感染。
Here we present a case series from a primate research facility. The index case, a 4-year-old pig-tailed macaque (Macaca nemestrina) experimentally infected with chimeric simian-human immunodeficiency virus (SHIVSF162 (P4)), developed weight loss and was euthanized. Based on necropsy results the animal was diagnosed with opportunistic atypical mycobacteriosis associated with simian AIDS (SAIDS). Subsequently, tissues from the index animal, as well as tissues and oral mucosal swabs from six SHIV-infected contacts, were analyzed using molecular methods and found to contain nucleic acid sequences characteristic of Mycobacterium tuberculosis complex (MTBC). These data suggest that existing protocols fail to reliably detect MTBC infection in laboratory primates used as experimental models.