Effect of oral contrast agents on computed tomography-based positron emission tomography attenuation correction in dual-modality positron emission tomography/computed tomography imaging.
Effect of oral contrast agents on computed tomography-based positron emission tomography attenuation correction in dual-modality positron emission tomography/computed tomography imaging.
复制标题
双模态正电子发射断层扫描/计算机断层扫描成像中口服造影剂对基于计算机断层扫描的正电子发射断层扫描衰减校正的影响。
DOI：
10.1097/01.rli.0000091651.69227.48
复制
发表时间：
2003
影响因子：
6.7
通讯作者：
A. Bockisch
中科院分区：
文献类型：
--
作者：
G. Antoch;W. Jentzen;L. Freudenberg;J. Stattaus;S. Mueller;J. Debatin;A. Bockisch
理论基础和目标
目的：评价基于正电子发射计算机断层扫描(CT)的正电子发射断层扫描(PET)双模式PET/CT的对比剂对比剂对衰减校正的影响。
方法
实验是在核医学会/国家电气制造商协会-PET模体上进行的，该模体配备了装有[18F]-2-氟-2-脱氧-D-葡萄糖的圆柱体。主隔室充满碘(0.5-10%)、钡(0.5%-50%)或水(阴性对照)。衰减校正的误差是通过比较在造影剂存在的情况下测量的示踪剂数量与预期数量来确定的。对比剂的衰减被证明与活体条件相当。
结果
造影剂的存在高估了PET图像上的血管内活度浓度，并与造影剂浓度(碘5-38%；钡15-580%)直接相关。临床应用中碘和钡的浓度导致对碘的活度高估20+/-1.8%，对钡的高估21+/-2.9%。
结论
如果PET衰减校正是基于CT的，那么在口服造影剂存在的情况下，可能会高估示踪剂的活度浓度。
RATIONALE AND OBJECTIVES
To evaluate the effect of iodine- and barium-based contrast agents on the computed tomography (CT)-based positron emission tomography (PET) attenuation correction in dual-modality PET/CT.
METHODS
Experiments were conducted on a Society of Nuclear Medicine/National Electrical Manufacturers Association-PET phantom equipped with cylinders containing [18F]-2-fluoro-2-desoxy-D-glucose. The main compartment was filled with iodine (0.5-10%), barium (0.5-50%), or water (negative control). The error in attenuation correction was determined by comparison of measured tracer quantities in the presence of contrast agents with expected quantities. Contrast agent attenuation was demonstrated to be comparable to in vivo conditions.
RESULTS
The presence of contrast agents resulted in an overestimation of the intracylindrical activity concentration on PET images and overestimation directly related to contrast concentrations (iodine 5-38%; barium 15-580%). Iodine and barium concentrations in clinical use resulted in an activity overestimation of 20 +/- 1.8% for iodine and 21 +/- 2.9% for barium.
CONCLUSION
An overestimation of the tracer activity concentration is to be expected in the presence of oral contrast agents, if PET attenuation correction is attained CT-based.
组合式 PET/CT 扫描仪：选择。
DOI：
--
发表时间：
2001
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Townsend,DW
通讯作者：
Townsend,DW
影响因子：
3.8
作者：
Kinahan, PE;Townsend, DW;Sashin, D
通讯作者：
Sashin, D