Building a Cocrystal by Using Supramolecular Synthons for Pressure-Accelerated Heteromolecular Azide-Alkyne Cycloaddition
Building a Cocrystal by Using Supramolecular Synthons for Pressure-Accelerated Heteromolecular Azide-Alkyne Cycloaddition
复制标题
利用超分子合成子进行压力加速杂分子叠氮化物-炔环加成反应构建共晶
DOI：
10.1002/chem.201900391
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Ma Yuguo
中科院分区：
文献类型：
--
作者：
Meng Xiao;Chen Changqing;Deng Xinyuan;Wang Zhangyuan;Chen Qi;Ma Yuguo
在羧酸和酰胺的超分子阴离子作用下，通过协同氢键和芳烃-全氟芳烃相互作用，实现了共晶中两个不同分子之间的叠氮-炔环加成反应.该反应可以通过使用具有优异区域选择性的普通液压设备的压力来加速，以产生1，4-三唑产物。固态产物中不存在脱羧副反应，表明该策略可以为传统溶液合成无法直接获得的产物提供一条绿色合成路线。
Facilitated by the supramolecular synthons of carboxylic acids and amides through cooperative hydrogen‐bonding and arene–perfluoroarene interactions, the azide–alkyne cycloaddition reaction between two different molecules in a cocrystal was achieved. This reaction could be accelerated by pressure using a common hydraulic press equipment with excellent regioselectivity to yield 1,4‐triazole products. The absence of decarboxylation side reactions in the products in the solid state demonstrated that this strategy can provide a green synthetic route for products not directly accessible by traditional syntheses in solution.