Early assessment of motor dysfunctions aids in successful occlusion of the middle cerebral artery
Early assessment of motor dysfunctions aids in successful occlusion of the middle cerebral artery
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DOI：
10.1097/00001756-199811160-00012
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发表时间：
1998-11-16
期刊：
影响因子：
1.7
通讯作者：
Nishino, H
中科院分区：
文献类型：
--
作者：
Borlongan, CV;Hida, H;Nishino, H
鼠类大脑中动脉栓塞，使用腔内纤维闭塞，产生类似中风症状的行为改变。该模型已被用于检查该疾病的治疗干预措施，然而，完全阻断大脑中动脉的不同成功率可能会对数据产生不确定的解释。为了检测大脑中动脉是否成功闭塞，我们在这里展示了敏感可靠的行为参数，包括升高的身体摆动测试、体位悬尾测试、自发旋转测试和前肢运动障碍测试。这些检测为鉴定不完全闭塞的动物提供了一个标准，不完全闭塞可能促进宿主相关的自发恢复，并可能混淆实验性治疗对缺血诱导功能障碍的真正影响。从实用的角度来看，早期可靠地识别脑局部缺血有助于立即有效地调整手术程序，以创建完整和稳定的缺血脑卒中动物模型。《神经科学报告》9 (C) 1998。
OCCLUSION of the rodent middle cerebral artery by embolism, using an intraluminal filament, produces behavioral alterations which resemble many symptoms associated with stroke. This model has been used to examine treatment interventions for the disease, however, variable success rate in completely blocking the middle cerebral artery may present inconclusive interpretation of the data. To detect successful occlusion of the middle cerebral artery, we demonstrate here sensitive and reliable behavioral parameters including the elevated body swing test, the postural tail-hang test, the spontaneous rotational test, and the forelimb akinesia test. These assays provide a criterion for identifying animals with incomplete occlusion which could promote host-related spontaneous recovery and might confound true effects of experimental therapies on ischemia-induced dysfunctions. From a practical standpoint, the early reliable identification of partial cerebral ischemia aids in immediate and efficient adjustments of the surgical procedure to create a complete and stable ischemia stroke animal model. NeuroReport 9: 3615-3621 (C) 1998 Lippincott Williams & Wilkins.