Percutaneous tumor ablation: Increased necrosis with combined radio-frequency ablation and intravenous liposomal doxorubicin in a rat breast tumor model
Percutaneous tumor ablation: Increased necrosis with combined radio-frequency ablation and intravenous liposomal doxorubicin in a rat breast tumor model
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DOI：
10.1148/radiol.2223010861
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发表时间：
2002-03-01
期刊：
影响因子：
19.7
通讯作者：
Kruskal, JB
中科院分区：
文献类型：
--
作者：
Goldberg, SN;Girnan, GD;Kruskal, JB
目得：为了确定是否结合静脉脂质体阿霉素和射频（RF）消融增加肿瘤破坏相比，RF单独在animal tumor model.MATERIALS和METHODS：R3230乳腺癌1.4-1.8厘米直径结节皮下植入132雌性Fischer大鼠。最初，肿瘤采用（a）常规单极射频治疗（平均值，250 mA +/- 25 [SD]，70 ℃ +/- 1，5分钟）单独消融，（B）RF消融后静脉内施用1 mg脂质体阿霉素，（c）RF消融后静脉内施用1 mg空脂质体，（d）RF消融和脂质体阿霉素的直接瘤内给药，或（e）不治疗。随后，剂量（0.06-2.00 mg）脂质体阿霉素，给药时间（射频消融前3天至消融后3天）和病理检查时间结果：治疗后肿瘤的平均凝固直径如下：6.7 mm ± 0.6，单独射频消融; 11.1 mm +/- 1.5，射频消融和静脉注射空脂质体（P <0.05，与单独射频消融相比）; 8.4 mm +/- 1.1，射频消融和瘤内注射脂质体阿霉素（P <0.05，与单独射频消融相比）。多柔比星脂质体和射频消融联合使用时，平均凝固直径最大增加（13.1 mm × 1.5 mm）（所有比较P <0.001）。联合治疗的凝血增加在治疗后48小时内发生。凝固直径并没有随着阿霉素的浓度范围而变化，并不依赖于从3天前到24小时后，RF ablation.CONCLUSION：静脉注射脂质体阿霉素的管理时间可以提高RF消融，因为它增加了凝固直径在实体瘤相比，单独的RF消融或结合RF消融与管理的空脂质体。(C)RSNA，2002年。
PURPOSE: To determine whether a combination of intravenous liposomal doxorubicin and radio-frequency (RF) ablation increases tumor destruction compared with RF alone in an animal tumor model.MATERIALS AND METHODS: R3230 mammary adenocarcinoma 1.4-1.8-cm-diameter nodules were implanted subcutaneously in 132 female Fischer rats. Initially, tumors were treated with (a) conventional, monopolar RF (mean, 250 mA +/- 25 [SD] at 70degreesC +/- 1 for 5 minutes) ablation alone, (b) RF ablation followed by intravenous administration of 1 mg of liposomal doxorubicin, (c) RF ablation followed by intravenous administration of 1 mg of empty liposomes, (d) RF ablation and direct intratumoral administration of liposomal doxorubicin, or (e) no treatment. Subsequently, the dose (0.06-2.00 mg) of liposomal doxorubicin, the timing of administration (3 days before to 3 days after RF ablation), and the time of pathologic examination (0-72 hours after treatment) were varied.RESULTS: Mean coagulation diameter for treated tumors follows: 6.7 mm +/- 0.6, RF ablation alone; 11.1 mm +/- 1.5, RF ablation and intravenous administration of empty liposomes (P < .05, compared with RF ablation alone); and 8.4 mm +/- 1.1, RF ablation with intratumoral administration of liposomal doxorubicin (P < .05, compared with RF ablation alone). Maximal increased mean coagulation diameter (13.1 mm 1.5) was observed with a combination of liposomal doxorubicin and RF ablation (P < .001, for all comparisons). The increased coagulation for combination therapy developed over 48 hours after therapy. Coagulation diameter did not vary with the doxorubicin concentration range and was not dependent on the timing of administration of liposomal doxorubicin from 3 days before to 24 hours after RF ablation.CONCLUSION: Intravenous administration of liposomal doxorubicin can improve RF ablation, since it increases coagulation diameter in solid tumors compared with RF ablation alone or a combination of RF ablation with administration of empty liposomes. (C) RSNA, 2002.