AMYOTROPHIC LATERAL SCLEROSIS - MACRO-EMG AND TWITCH FORCES OF SINGLE MOTOR UNITS
AMYOTROPHIC LATERAL SCLEROSIS - MACRO-EMG AND TWITCH FORCES OF SINGLE MOTOR UNITS
复制标题
DOI：
10.1002/mus.880130612
复制
发表时间：
1990-06-01
期刊：
影响因子：
3.4
通讯作者：
STRUPPLER, A
中科院分区：
文献类型：
--
作者：
DENGLER, R;KONSTANZER, A;STRUPPLER, A
在10例正常人和20例肌萎缩侧索硬化症(ALS)患者的第一背侧骨间肌(FDi)上，记录了单个运动单位的大肌电、S和抽动收缩(峰触发平均)。对MUS全范围志愿征集门槛进行了研究。轻度受累的FDI患者(5)主要表现为MU，MEP增大，痉挛力量增强。相比之下，受影响更严重的FDI患者表现出抽动力降低，特别是在阈值较高的MU中。相应的MEP可以增大，也可以正常。在ALS的早期阶段，MU的萌发和由此引起的抽动力的增加似乎可以补偿运动神经元的丢失。然而，在更高级的阶段，存活的MU力量的下降，特别是那些阈值较高的MU，似乎除了皮质脊髓变性和运动神经元数量减少外，似乎还导致进行性肌肉无力。
Macro-EMG potentials (MEP)s and twitch contractions (spike-triggered-averaging) of single motor units (MUs) have been recorded in the first dorsal interosseus muscle (FDI) of 10 control subjects and 20 patients with amyotrophic lateral sclerosis (ALS). MUs over the full range of voluntary recruitment thresholds were studied. Patients with slightly affected FDIs (5) mainly showed MUs with enlarged MEPs and increased twitch forces. In contrast, the patients with more severely affected FDIs (15) revealed decreased twitch forces, especially in the MUs with higher thresholds. The corresponding MEPs could be enlarged as well as normal. It appears that MU sprouting and the resulting increase of twitch force can compensate for the loss of motoneuron in early stages of ALS. In more advanced stages, however, a decline of the force of the surviving MUs, especially of those with higher thresholds, seems to contribute to the progressive muscle weakness, in addition to the corticospinal degeneration and the reduction in the number of motoneurons.