Percutaneous absorption of ketoprofen from acrylic gel patches containing d-limonene and ethanol as absorption enhancers.
Percutaneous absorption of ketoprofen from acrylic gel patches containing d-limonene and ethanol as absorption enhancers.
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含有 d-柠檬烯和乙醇作为吸收促进剂的丙烯酸凝胶贴剂经皮吸收酮洛芬。
DOI：
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发表时间：
1992
影响因子：
1.7
通讯作者：
T. Nagai
中科院分区：
文献类型：
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作者：
H. Okabe;K. Takayama;T. Nagai
研究了酮洛芬（KPF）凝胶贴剂在大鼠体内的经皮吸收。KPF的血浆水平随构成凝胶贴剂的聚合物的种类而变化，当丙烯酸乙酯（EA）和甲基丙烯酸二乙二醇酯（DEGMA）的共聚物用作载体时观察到最高水平。KPF从凝胶贴剂透过大鼠皮肤的量与乙醇的量具有良好的相关性。随着从载体分布到皮肤组织的d-柠檬烯的量的增加，渗透增强。皮肤中积累的d-柠檬烯的量随聚合物的种类而变化很大;在EA-DEGMA共聚物中观察到最高的积累，并且随着d-柠檬烯对聚合物的亲和力的增加而降低。EA-DEGMA共聚物从含有d-柠檬烯的凝胶贴剂中显示出最高的KPF经皮吸收的原因可能是该聚合物的亲水性，其显示出对d-柠檬烯的最低亲和力。
The percutaneous absorption of ketoprofen (KPF) from gel patches containing d-limonene and ethanol was investigated in rats. Plasma levels of KPF varied with the kind of polymers which constitute the gel patch, and the highest level was observed when the copolymer of ethylacrylate (EA) and diethyleneglycolmethacrylate (DEGMA) was used as a vehicle. The amount of KPF permeating through the rat skin from the gel patch was well correlated with that of ethanol. Permeations were enhanced with increase in the amount of d-limonene distributed from the vehicle to the skin tissue. The amount of d-limonene accumulated in the skin varied greatly with the kind of polymers; the highest accumulation was observed with the EA-DEGMA copolymer, and decreased with increasing affinity of d-limonene to the polymers. The reason EA-DEGMA copolymer showed the highest percutaneous absorption of KPF from gel patches containing d-limonene may be the hydrophilic nature of this polymer which showed the lowest affinity to d-limonene.