Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy
Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy
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用于氧化还原响应基因传递和协同癌症化疗的大孔径中空介孔有机二氧化硅
DOI：
10.1002/adma.201505524
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发表时间：
2016-03-09
影响因子：
29.4
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Wu, Meiying;Meng, Qingshuo;Shi, Jianlin
本文提出了一种利用稳定性差异选择性断键的方法制备大孔径中空介孔有机硅纳米粒子。此外，表面功能化的HMONs被成功地构建为同时递送P-gp调节剂siRNA和抗癌药物阿霉素以逆转癌细胞的多药耐药性。
A stability-difference-selective bond-breakage strategy for the fabrication of large-pore-sized hollow mesoporous organosilica nanoparticles (HMONs) is successfully developed. Moreover, surface-functionalized HMONs are successfully constructed to simultaneously deliver P-gp modulator siRNA and anticancer drug doxorubicin to reverse the multidrug resistance of cancer cells.