Nonparametric sequential evaluation of diagnostic biomarkers
Nonparametric sequential evaluation of diagnostic biomarkers
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DOI：
10.1002/sim.3203
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发表时间：
2008-05-10
影响因子：
2
通讯作者：
Schisterman, Enrique F.
中科院分区：
文献类型：
--
作者：
Liu, Aiyi;Wu, Chengqing;Schisterman, Enrique F.
我们考虑评估和比较生物标志物的诊断准确性与连续测试结果，可能由于重复测量而相关。我们开发非参数组序贯测试程序，以评估和比较受试者操作特征曲线下生物标志物的面积，以及独立或配对的测试结果。这些程序依赖于 Whitehead 二维统计的构造（Statist. Med. 1999；18：2271-2286），以便可以应用基于布朗运动的设计方法。版权所有 (C) 2008 约翰·威利父子有限公司
We consider evaluation and comparison of the diagnostic accuracy of biomarkers with continuous test outcomes, possibly correlated due to repeated measurements. We develop nonparametric group sequential testing procedures to evaluate and compare the area of biomarkers under their receiver operating characteristic curves, with either independent or paired test outcomes. These procedures rely on the construction of a two-dimensional statistic of Whitehead (Statist. Med. 1999; 18:2271-2286) so that design methods based on Brownian motion can be applied. Copyright (C) 2008 John Wiley & Sons, Ltd.