A pigmented calcifying cystic odontogenic tumor associated with compound odontoma: a case report and review of literature.
A pigmented calcifying cystic odontogenic tumor associated with compound odontoma: a case report and review of literature.
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DOI：
10.1186/1746-160x-3-35
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发表时间：
2007-09-25
影响因子：
3
通讯作者：
Nagai, Noriyuki
中科院分区：
文献类型：
--
作者：
Han, Phuu P;Nagatsuka, Hitoshi;Nagai, Noriyuki
背景：色素在骨内牙源性病变是罕见的，只有47例报告的英文文献。其中，色素钙化性囊性牙源性肿瘤（原名钙化性牙源性囊肿）是最常见的病变，共报告20例。方法：一个病例的色素钙化囊性牙源性肿瘤与牙瘤发生在一个年轻的日本男孩的下颌犬-前磨牙区域提出了x线摄影和组织学结果。特殊染色、电镜和免疫组织化学染色对色素沉着进行了表征。结果：马松-丰塔纳染色及透射电镜证实病灶内色素为黑色素。S-100免疫染色也显示病变内存在树突状黑色素细胞。结论：本病例报告的色素钙化囊性牙源性肿瘤合并牙瘤对黑色素和黑色素细胞进行了全面的研究，包括组织化学、免疫组织化学和透射电镜检查结果。
BACKGROUND: Pigmented intraosseous odontogenic lesions are rare with only 47 reported cases in the English literature. Among them, pigmented calcifying cystic odontogenic tumor, formerly known as calcifying odontogenic cyst, is the most common lesion with 20 reported cases.METHODS: A case of pigmented calcifying cystic odontogenic tumor associated with odontoma occurring at the mandibular canine-premolar region of a young Japanese boy is presented with radiographic, and histological findings. Special staining, electron microscopic study and immunohistochemical staining were also done to characterize the pigmentation.RESULTS: The pigments in the lesion were confirmed to be melanin by Masson-Fontana staining and by transmission electron microscopy. The presence of dendritic melanocytes within the lesion was also demonstrated by S-100 immunostaining.CONCLUSION: The present case report of pigmented calcifying cystic odontogenic tumor associated with odontoma features a comprehensive study on melanin and melanocytes, including histochemical, immunohistochemical and transmission electron microscopic findings.