UNIVARIATE AND BIVARIATE ANALYSES OF CHOLESTEROL AND TRIGLYCERIDE LEVELS IN PEDIGREES
UNIVARIATE AND BIVARIATE ANALYSES OF CHOLESTEROL AND TRIGLYCERIDE LEVELS IN PEDIGREES
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DOI：
10.1002/ajmg.1320230306
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发表时间：
1986-03-01
期刊：
影响因子：
--
通讯作者：
KOTTKE, BA
中科院分区：
文献类型：
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作者：
BOEHNKE, M;MOLL, PP;KOTTKE, BA
采用多变量正态模型对来自美国明尼苏达州罗切斯特的95个家系的771名个体进行空腹血清总胆固醇和血清总甘油三酯测定。进行单变量和双变量分析，以确定在何种程度上这两个性状的家庭的聚集和共聚集可能归因于共享的遗传和环境因素。通过对血清胆固醇水平在其年龄和性别特异性分布的最高和最低十分位数中的学龄儿童进行富集，确定谱系。通过先证者特征值的可能性来校正确定。单变量结果证实了以前的研究结果表明，血清胆固醇和甘油三酯水平的家族聚集是由于共享的基因和共享的环境因素。双变量分析的结果表明，在这些家庭的胆固醇和甘油三酯水平的共聚集的强烈影响，共享的基因（多效性）和共享的环境因素。这些发现与我们对脂质代谢和已知影响这两种性状的特定环境因素的理解一致。
A multivariate normal model for pedigree analysis is applied to fasting total serum cholesterol and total serum triglyceride measurements on 771 individuals in 95 pedigrees from Rochester, MN [USA]. Univariate and bivariate analyses are carried out to determine to what extent the aggregation and coaggregation in families of these two traits may be attributed to shared genetic and environmental factors. Pedigrees were ascertained through a sample of schoolchildren enriched for those with serum cholesterol levels in the highest and lowest deciles of their age- and sex-specific distributions. Ascertainment is corrected for by conditioning the likelihood on the trait values of the probands. Univariate results confirm the findings of previous studies indicating that familial aggregation of serum cholesterol and triglyceride levels is due both to shared genes and to shared environmental factors. Results of the bivariate analyses suggest that the coaggregation of cholesterol and triglyceride levels in these families is strongly influenced by both shared genes (pleiotropy) and shared environmental factors. These findings are consistent with our understanding of lipid metabolism and of specific environmental factors known to influence both traits.