EFFECTS OF PROSTAGLANDINS E1, E2, F1α, F2α ON ISOLATED HUMAN UMBILICAL AND PLACENTAL BLOOD VESSELS
EFFECTS OF PROSTAGLANDINS E1, E2, F1α, F2α ON ISOLATED HUMAN UMBILICAL AND PLACENTAL BLOOD VESSELS
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前列腺素 E1、E2、F1α、F2α 对离体人脐带和胎盘血管的影响
DOI：
10.1111/j.1471-0528.1968.tb00178.x
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
S. Karim
中科院分区：
文献类型：
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作者：
K. Hillier;S. Karim
脐循环是母亲和胎儿在宫内生存的重要联系;它不仅是气体和代谢交换的途径，而且也是胎儿循环中全身血管阻力的唯一最重要的决定因素（Dawes，1962）。因此，刺激脐带和胎盘血管的生物血管活性物质在胎儿生理学和药理学中是令人感兴趣的，并且这些已经成为许多研究的主题（Euler，1938; Panigel，1962; Takaneka，1963; Somlyo等，1965; Karim，1966，1967; Astrom和Samelius，1957）。在出生时，脐带血管最重要的功能是完全闭合，尤其是在动物产科中，似乎存在一种适当的生理机制来停止脐带血的流动（Rachmanow，1914; Price，1944;威廉姆斯，1931）。Karim（1966）考虑到化学物质可能参与了出生时脐带血管的闭合，研究了足月自然阴道分娩的脐带提取物，发现了几种平滑肌刺激羟基脂肪酸。这些后来被鉴定为E1，E，，F，和F，，（Karim，1967）。结果表明，这些血管紧张素具有活性或：脐动脉的纵带。发现PGE_2、PGE_3、PGF_（1-x）可引起离体肌肉缩短和PGE_3松弛。这四个arylandins对人脐和胎盘血管的孤立的环形和纵向肌肉制备在任期和在怀孕的各个阶段的影响进行了调查。
THE umbilical circulation is the vital link between the mother and the fetus in its intrauterine existence; not only is it the pathway for gaseous and metabolic exchange, but it is also the single most important determinant of systemic vascular resistance within the fetal circulation (Dawes, 1962). Biological vasoactive substances which stimulate cord and placental vessels are therefore of interest in fetal physiology and pharmacology, and these have been the subject of much investigation (Euler, 1938; Panigel, 1962; Takaneka, 1963; Somlyo et al., 1965; Karim, 1966, 1967; Astrom and Samelius, 1957). At birth the most important function of the cord vessels, especially in animal obstetrics, is complete closure, and an adequate physiological mechanism appears to exist for the cessation of umbilical blood flow (Rachmanow, 1914; Price, 1944; Williams, 1931). Karim (1966) considering the possible involvement of a chemical substance in closure of the cord vessels at birth investigated extracts of cords from spontaneous vaginal deliveries at term, and found several smooth-muscle-stimulating hydroxy fatty acids. These were later identified as prostaglandins El, E,, F,, and F,, (Karim, 1967). These prostaglandins were shown to be active or: the longitudinal strips of the umbilical artery. PGE,, PGE,,, PGF,, were found to cause shortening of the isolated muscle and PGE, relaxation. An investigation into the effects of these four prostaglandins on isolated circular and longitudinal muscle preparations of human umbilical and placental vessels at term and at various stages of pregnancy has been carried out.