Leaving histone unturned for epigenetic inheritance.
Leaving histone unturned for epigenetic inheritance.
复制标题
使组蛋白不参与表观遗传。
DOI：
10.1111/febs.16260
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Jia,Songtao
中科院分区：
文献类型：
--
作者：
Shan,Chun-Min;Fang,Yimeng;Jia,Songtao
组蛋白的翻译后修饰在调节染色质结构和基因表达程序中起着重要作用，并且修饰的组蛋白可以作为表观遗传记忆传递给后代。裂殖酵母是研究异染色质组装和表观遗传中组蛋白修饰的重要模式生物。在这里，我们回顾了这种生物体中的发现，这些发现巩固了基于染色质的遗传的想法，并强调了最近揭示组蛋白更替在调节这一过程中的作用的研究。
Post‐translational modifications in histones play important roles in regulating chromatin structure and gene expression programs, and the modified histones can be passed on to subsequent generations as an epigenetic memory. The fission yeast has been a great model organism for studying histone modifications in heterochromatin assembly and epigenetic inheritance. Here, we review findings in this organism that cemented the idea of chromatin‐based inheritance and highlight recent studies that reveal the role of histone turnover in regulating this process.