Bilio‐pancreatic bypass for obesity: II. Initial experience in man
Bilio‐pancreatic bypass for obesity: II. Initial experience in man
复制标题
胆胰旁路术治疗肥胖：II。
作者：
N. Scopinaro;E. Gianetta;D. Civalleri;U. Bonalumi;V. Bachi
在犬胆胰分流术试验成功后，在18名患者中完成了一项临床研究，随访时间超过1年。对手术进行了改良，以达到最佳的减重效果，并形成与消化道等长的胆胰道和较短的回肠总道，平均减重占术前体重的百分比为24.1 ± 5.4%（平均值±标准差）。6个月时为33.7 ± 4.1%，12个月时为33.7 ± 4.1%。唯一的即刻并发症是伤口裂开，无晚期并发症。肝功能检查显示无肝脏恶化，肝活检显示术后1年肝脏形态改善。这表明，在肥胖症的治疗中，该手术可能是空回肠旁路术的替代方案。
After a successful trial of bilio‐pancreatic bypass in dogs, a clinical study has been completed in 18 patients followed for more than 1 year. The operation has been modified to achieve the best weight reduction, and forming the bilio‐pancreatic tract of equal length to the alimentary tract with a short common ileal tract, the average weight loss as a percentage of the preoperative body weight was 24·1 ± 5·4 per cent (mean ± s.d.) at 6 months and 33·7 ± 4·1 per cent at 12 months. The only immediate complication was a wound dehiscence, and there were no late complications. Liver function studies showed the absence of hepatic deterioration and liver biopsies showed improvement of liver morphology 1 year after the operation. It is suggested that this procedure may be an alternative to jejuno‐ileal bypass in the management of obesity.