Quality of life following high-intensity focused ultrasound for the treatment of localized prostate cancer: A prospective study
Quality of life following high-intensity focused ultrasound for the treatment of localized prostate cancer: A prospective study
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DOI：
10.1111/j.1442-2042.2010.02568.x
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发表时间：
2010-08-01
影响因子：
2.6
通讯作者：
Uchida, Toyoaki
中科院分区：
文献类型：
--
作者：
Shoji, Sunao;Nakano, Mayura;Uchida, Toyoaki
目的：报告我们的健康相关的生活质量（QOL）和功能的结果后，高强度聚焦超声（HIFU）局部prostate cancer.Methods：数据从前列腺癌患者接受HIFU在我们的机构1999年1月至2007年4月收集在我们的前瞻性数据库。包括标准术前和手术参数，以及基线尿功能，QOL和性评估。使用日本版癌症治疗功能评估（FACT-G）、FACT-prostate（P）和国际勃起功能指数-5（IIEF-5）进行功能评估。这些自填式问卷在术前和术后6个月、12个月和24个月再次收集。最大尿流率和残余尿量在HIFU治疗后6个月显著受损（P = 0.010），即使在HIFU治疗后12或24个月恢复到基线值。HIFU治疗后24个月，FACT-G总评分显著改善（P = 0.027）。在6，12和24个月后，HIFU，52%，63%和78%的患者，不接受新辅助激素治疗，分别是potent.Conclusions：在我们的经验，局部前列腺癌HIFU治疗后的功能和生活质量的结果优于其他治疗方式。
Objectives:To report our health-related quality of life (QOL) and functional outcomes following high-intensity focused ultrasound (HIFU) for localized prostate cancer.Methods:Data from prostate cancer patients undergoing HIFU at our institution between January 1999 and April 2007 were collected in our prospective database. Standard preoperative and surgical parameters, as well as baseline urinary function, QOL and sexual assessment were included. The Japanese version of the Functional Assessment of Cancer Therapy-general (FACT-G), the FACT-prostate (P) and the International Index of Erectile Function-5 (IIEF-5) were used for the functional assessment. These self-administered questionnaires were collected preoperatively and again at 6, 12 and 24 months postoperatively.Results:A total of 326 patients were included in the analysis. Maximum flow rate and residual urine volume were significantly impaired at 6 months (P = 0.010) after HIFU, even if they returned to baseline values at 12 or 24 months after HIFU. The total FACT-G score significantly improved at 24 months (P = 0.027) after HIFU. At 6, 12 and 24 months after HIFU, 52%, 63% and 78%, respectively, of the patients, not receiving neoadjuvant hormonal therapy, were potent.Conclusions:In our experience, functional and QOL outcomes after HIFU therapy for localized prostate cancer are better than those after other treatment modalities.