GAPs: Terminator versus effector functions and the role(s) of ArfGAP1 in vesicle biogenesis.
GAPs: Terminator versus effector functions and the role(s) of ArfGAP1 in vesicle biogenesis.
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DOI：
10.4161/cl.1.2.15153
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发表时间：
2011-03
期刊：
影响因子：
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通讯作者：
R. Kahn
中科院分区：
文献类型：
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作者：
R. Kahn
无论你的热情是了解和逆转疾病过程，还是更好地了解细胞如何工作，今天任何希望了解细胞调控的人都必须对调控GTP酶机制及其在特定途径中的应用有详细和准确的了解。随着GTP酶不同家族成员及其监管者发出信号的细节的扩大，这一点变得越来越困难。但这就更有理由不断地问，GTP酶信号的哪些方面与GTP酶或其亚家族不同，哪些在整个超家族中是保守的？我们每个人对GTP酶信号转导的关键方面的看法略有不同，这些关键方面来自我们自己的实验室研究的主要GTP酶；例如，转位到膜上是Arf激活的基本和不可或缺的方面，而不是其他GTP酶的关键方面。然而，GTPase信号的一个方面，我已经开始相信是广泛的和具有普遍重要性的，并没有被普遍接受。事实上，通过我在最近的FASEB夏季研究会议上关于ARF家族GTP酶的对话和在研究生辅导班上阅读文献，我意识到它并不被大多数研究人员所了解或接受。问题是GTP酶激活蛋白(GAP)在信号传递中的作用。它们是信号的“纯粹”终结者，还是提供效应器功能？
Whether your passion is to understand and reverse disease processes or "simply" a better understanding of how cells work, anyone wishing to understand cell regulation today must have a detailed and accurate understanding of regulatory GTPase mechanisms and their application to specific pathways. This is becoming increasingly difficult as the details of signaling by members of different families of GTPases and their regulators expand. But this is all the more reason to continually ask, which aspects of GTPase signaling are distinct to a GTPase or its subfamily and which are conserved throughout the superfamily? We each have slightly different views of the key aspects of GTPase signaling that are derived from the main GTPases studied in our own labs; e.g., translocation onto a membrane is an essential and integral aspect of Arf activation but not of other GTPases. However, one aspect of GTPase signaling that I had come to believe to be widespread and of general importance is not universally accepted. In fact, through my conversations at the recent FASEB summer research conference on "Arf Family GTPases" and reading of the literature in a graduate tutorial class, I realized that it is not known or accepted by the majority of researchers. The question is the role of GTPase activating proteins (GAPs) in signaling. Are they "pure" terminators of signaling or do they serve effector functions?