Blood pressure reduction and vascular adaptation. A study on long-term effects of treatment with mefruside or atenolol.
Blood pressure reduction and vascular adaptation. A study on long-term effects of treatment with mefruside or atenolol.
复制标题
血压降低和血管适应。
DOI：
10.1111/j.0954-6820.1979.tb06088.x
复制
发表时间：
2009
影响因子：
--
通讯作者：
L. Hansson
中科院分区：
文献类型：
--
作者：
R. Sivertsson;O. Andersson;L. Hansson
对42例未经治疗的轻中度原发性高血压（WHO I ~ WHO II）患者，分别用甲呋糖苷（25 mg/d）或阿替洛尔（100--400mg/d）降压治疗前、后6周、6个月和18个月，测定了全身血压下降、小腿血流和小腿血管阻力。在仰卧位患者中，使用橡胶汞应变计技术通过静脉闭塞体积描记术测定血流量。在测定流量的同时测量右臂的听诊BP，并根据流量和压力计算阻力。两种药物均能显著降低血压，降低程度相同。在阿替洛尔组中，最初观察到静息阻力上升和相应的静息血流量下降。这些变化在持续治疗18个月期间完全正常化。在甲呋酯组中，除了血压下降外，在休息时未观察到治疗期间的显著血流动力学变化。没有一种药物在“最大”血管舒张时降低阻力，表明小腿血管的高血压结构变化没有消退。
Systemic BP reduction, calf blood flow and vascular resistance in the calf were determined in forty-two previously untreated patients with mild to moderate essential hypertension (WHO I-WHO II) before and after 6 weeks, 6 months and 18 months of BP-lowering treatment with mefruside (25 mg daily) or atenolol (100--400 mg daily). Blood flow was determined with venous occlusion plethysmography using a mercury-in-rubber strain gauge technique in the supine patient. Auscultatory BP was measured on the right arm simultaneously with the flow determinations and resistance was calculated from the flow and pressure. BP was reduced significantly and to the same extent by the two drugs. In the atenolol group a rise in resting resistance and a corresponding fall in resting blood flow was seen initially. These changes were entirely normalized during continued treatment for 18 months. In the mefruside group no significant haemodynamic changes during treatment were observed at rest apart from the BP fall. None of the drugs reduced resistance at "maximal" vasodilatation, indicating that no regress of the hypertensive structural changes of the calf blood vessels had taken place.