Radiologic assessment of intranodal vascularity in head and neck squamous cell carcinoma. Correlation with histologic vascular density.
Radiologic assessment of intranodal vascularity in head and neck squamous cell carcinoma. Correlation with histologic vascular density.
复制标题
头颈鳞状细胞癌结内血管的放射学评估。
作者：
S. Lamer;R. Sigal;N. Lassau;J. Bosq;F. Frouin;M. Di Paola;G. Mamelle;J. Leclère;J. Bittoun;R. Di Paola
依据和目标
头颈部鳞状细胞癌的淋巴结对化疗的反应取决于血管化。作者评估了检测淋巴结血管化的不同技术。
方法
纳入了14例手术治疗前的头颈部肿瘤患者。最大的转移性淋巴结（平均轴向扫描直径30 x 20 mm）通过彩色和脉冲多普勒和动态磁共振图像进行研究，并通过医学图像序列因子分析（FAMIS）进行处理，估计生理对比增强动力学（因子）及其空间分布（因子图像）。结果与组织学微血管密度（MVD）进行比较。使用光学显微镜，通过血管表面（通过染色内皮细胞）与基质表面的比率x 100估计MVD。
结果
FAMIS确定了三个因子：坏死中的恒定因子，正常淋巴区和肿瘤间质中较早的F1因子和较晚的F2因子。当MVD> 6.36时，可检测到彩色血流信号。
结论
FAMIS仅提取了一种血管化模型，肿瘤和备用淋巴区之间没有差异。彩色血流信号的存在有助于预测转移淋巴结对化疗的反应。
RATIONALE AND OBJECTIVES
Nodal response to chemotherapy in head and neck squamous cell carcinoma depends on the vascularization. The authors assessed different techniques in detecting nodal vascularization.
METHODS
Fourteen patients with head and neck tumor were included before surgical treatment. The largest metastatic lymph node (mean axial scanographic diameters 30 x 20 mm) was studied by color and pulsed Doppler, and dynamic magnetic resonance images, processed by factor analysis of medical image sequences (FAMIS), which estimates physiologic contrast enhancement kinetics (factors) and their spatial distributions (factor images). Results were compared with the histologic microvessel density (MVD). Using light microscopy, MVD was estimated by the vascular surface (by staining endothelial cells) to the stroma surface ratio x 100.
RESULTS
Three factors were identified by FAMIS: a constant factor in necrosis, an earlier F1 factor and a later F2 factor in normal lymphoid areas and neoplastic stroma. Color flow signal was detected when the MVD was greater than 6.36.
CONCLUSIONS
Only one model of vascularization was extracted by FAMIS, with no difference between neoplastic and spared lymphoid areas. The presence of color-flow signals could help predict the response of metastatic lymph nodes to chemotherapy.
影响因子：
158.5
作者：
WEIDNER, N;SEMPLE, JP;FOLKMAN, J
通讯作者：
FOLKMAN, J