Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis
Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis
复制标题
DOI：
10.1096/fj.12-221994
复制
发表时间：
2013-04-01
期刊：
影响因子：
4.8
通讯作者：
Hernando, Eva
中科院分区：
文献类型：
--
作者：
Danielson, Laura S.;Park, David S.;Hernando, Eva
microRNA簇miR-17-92与心血管发育和功能有关，但在这些情况下的精确作用机理尚不确定。这项研究旨在研究miR-17-92在心脏和平滑肌组织的形态发生和功能中的作用。为此，产生了miR-17-92中有条件过表达的小鼠模型在心脏和平滑肌组织中。广泛的心脏功能研究确定了转基因动物的扩张，肥厚性心肌病和心律不齐的诱导性的剂量依赖性诱导，这与早亡率过早有关（98.3 +/- 42.5 D，P，P，P
MicroRNA cluster miR-17-92 has been implicated in cardiovascular development and function, yet its precise mechanisms of action in these contexts are uncertain. This study aimed to investigate the role of miR-17-92 in morphogenesis and function of cardiac and smooth muscle tissues. To do so, a mouse model of conditional overexpression of miR-17-92 in cardiac and smooth muscle tissues was generated. Extensive cardiac functional studies identified a dose-dependent induction of dilated, hypertrophic cardiomyopathy, and arrhythmia inducibility in transgenic animals, which correlated with premature mortality (98.3+/-42.5 d, P