Remissions induced in hereditary angioneurotic edema with an attenuated androgen (danazol): correlation between concentrations of C1-inhibitor and the forth and second components of complement.
Remissions induced in hereditary angioneurotic edema with an attenuated androgen (danazol): correlation between concentrations of C1-inhibitor and the forth and second components of complement.
复制标题
用减毒雄激素（达那唑）诱导遗传性血管神经性水肿缓解：C1 抑制剂浓度与补体第四和第二成分之间的相关性。
DOI：
10.5555/uri:pii:0022214378900999
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
R. Wyatt
中科院分区：
文献类型：
--
作者：
J. S. Pitts;V. Donaldson;J. Forristal;R. Wyatt
Serum concentrations of antigenic and functional C1-INH increased in patients in whom remissions from attacks of HANE were induced with danazol. The levels of C4 were directly related to serum concentrations of C1-INH antigens up to a concentration of about half the C1-INH found in normal plasma; at this point, the C4 concentrations were in the normal range and no longer correlated well with C1-INH concentration. Serum C2 levels correlated less well with C1-INH concentration. In normal serum there was a poor correlation between C1-INH, C4, and C2 levels, suggesting that C1-INH is normally present in excess of the amount needed for normal C4 levels. The increments in serum C1-INH were related to the dose of danazol.
