Long-lasting improved amino acid bioavailability associated with protein pulse feeding in hospitalized elderly patients: A randomized controlled trial
Long-lasting improved amino acid bioavailability associated with protein pulse feeding in hospitalized elderly patients: A randomized controlled trial
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DOI：
10.1016/j.nut.2013.10.006
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发表时间：
2014-05-01
期刊：
影响因子：
4.4
通讯作者：
Aussel, Christian
中科院分区：
文献类型：
--
作者：
Bouillanne, Olivier;Neveux, Nathalie;Aussel, Christian
目的：衰老与食物摄入引起的合成代谢反应迟钝有关，可能与系统可利用氨基酸(AAs)减少有关，后者可能源于内脏AA代谢增加。内脏隔离可以通过脉冲喂养达到饱和(每天蛋白质摄入量的80%在一顿饭中)，从而增加蛋白质合成。这项研究的目的是探讨蛋白质脉冲喂养是否增加了餐后AA浓度，如果是的话，这种增加在饮食治疗6wk后是否持续。方法：这项前瞻性随机研究纳入了住院康复病房的66名老年营养不良或高危患者。所有受试者均给予6wk的控制饮食。在分散饮食(SD)组(n=36)，饮食蛋白质分布在每天的四餐中。在脉冲饮食(PD)组(n=30)，中午一餐消耗了72%的膳食蛋白质(平均每天1.31g/kg体重)。分别于第1天和第6周测定血浆AA浓度(0~+180min共5次)。结果：蛋白质脉冲喂养法比蛋白质涂抹喂养法更能有效地提高餐后血浆AA浓度，尤其是必需氨基酸。这一增加的餐后AA生物利用度在6周后保持不变。结论：本研究表明，蛋白质脉冲喂养引起的餐后AA生物利用度增加在6周后持续(即没有代谢适应钝化AA的生物利用度)。(C)2014 Elsevier Inc.保留所有权利。
Objective: Aging is associated with a blunted anabolic response to dietary intake, possibly related to a decrease in systemically available amino acids (AAs), which in turn may stem from increased splanchnic AA metabolism. Splanchnic sequestration can be saturated by pulse feeding (80% of daily protein intake in a single meal), enabling increased protein synthesis. The aim of this study was to explore whether protein pulse feeding increased postprandial AA concentrations, and if so whether this increase persisted after 6 wk of dietary treatment.Methods: This prospective randomized study enrolled 66 elderly malnourished or at-risk patients in an inpatient rehabilitation unit. All were given a controlled diet for 6 wk. In a spread diet (SD) group (n = 36), dietary protein was spread over the four daily meals. In a pulse diet (PD) group (n = 30), 72% of dietary protein (averaging 1.31 g/kg body weight daily) was consumed in one meal at noon. The patients were evaluated on day 1 and at 6 wk for plasma postprandial (five times from 0 to +180 min) AA concentrations (expressed as area under the curve above baseline).Results: Protein pulse feeding was more efficient than protein spread feeding at increasing plasma postprandial AA concentrations, notably of essential AAs. This increased postprandial AA bioavailability was maintained after 6 wk.Conclusions: This study demonstrates that increased postprandial AA bioavailability induced by protein pulse feeding persists after 6 wk (i.e., that there is no metabolic adaptation blunting AA bioavailability). (C) 2014 Elsevier Inc. All rights reserved.