Ficolins and infectious diseases
Ficolins and infectious diseases
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Ficolins 和传染病。
DOI：
10.1007/s12250-014-3421-2
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发表时间：
2014-02-01
影响因子：
5.5
通讯作者：
Zhang, Xiaolian
中科院分区：
文献类型：
--
作者：
Ren, Yushan;Ding, Quanquan;Zhang, Xiaolian
Ficolins是血清补体凝集素，其结构类似于甘露糖结合凝集素（MBL）和肺表面活性蛋白（SP）-A和SP-D。Ficolins激活凝集素补体系统，在宿主天然免疫中发挥重要作用。无花果蛋白酶是蛋白质的聚集蛋白家族的成员，其充当模式识别受体（PRR）。它们是具有凝集素样活性的可溶性寡聚防御蛋白，并且能够识别病原体相关分子模式（PAMP），其是病原体以及凋亡、坏死和恶性细胞表面上的碳水化合物分子。与其特异性PAMP结合后，纤维胶凝蛋白可以触发免疫系统的激活（1）通过凝集素途径启动补体激活，（2）通过原始类型的调理吞噬作用，或（3）通过刺激炎症细胞因子干扰素（IFN）的分泌-I”、白细胞介素（IL）-17、IL-6和肿瘤坏死因子（TNF）-α，以及由巨噬细胞产生一氧化氮（NO），从而限制感染并同时协调随后的适应性免疫应答。近年来，大量研究表明纤维胶凝蛋白的功能障碍或表达异常可能在病毒性和细菌性疾病以及炎症中起重要作用。本文综述了纤维胶凝蛋白在感染性疾病中的作用，并对纤维胶凝蛋白作为治疗这些疾病的新型天然免疫治疗选择提供了见解。
Ficolins are serum complement lectins, with a structure similar to mannose-binding lectin (MBL) and lung surfactant protein (SP)-A and SP-D. Ficolins activate the lectin complement system and play important roles in host innate immunity. Ficolins are members of the collectin family of proteins, which act as pattern recognition receptors (PRRs). They are soluble oligomeric defense proteins with lectin-like activity, and are able to recognize pathogen-associated molecular patterns (PAMPs), which are carbohydrate molecules on the surface of pathogens, and of apoptotic, necrotic, and malignant cells. Upon binding to their specific PAMPs, ficolins may trigger activation of the immune system either (1) by initiating activation of complement via the lectin pathway, (2) by a primitive type of opsonophagocytosis, or (3) by stimulating secretion of the inflammatory cytokines interferon (IFN)-I", interleukin (IL)-17, IL-6, and tumor necrosis factor (TNF)-alpha, and production of nitric oxide (NO) by macrophages, thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. Recently, a number of reports have shown that dysfunction or abnormal expression of ficolins may play crucial roles in viral and bacterial diseases and in inflammation. This review summarizes the reports on the roles of ficolins in the infectious diseases, and provides insight into ficolins as novel innate immune therapeutic options to treat these diseases.