Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin.
Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin.
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人类结肠腺癌细胞系的分离和表征对阿霉素的抗性。
DOI：
10.1038/bjc.1986.206
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发表时间：
1986-09
影响因子：
8.8
通讯作者：
Giuliani, F C
中科院分区：
文献类型：
--
作者：
Grandi, M;Geroni, C;Giuliani, F C
对阿霉素（DX）的抗性经常出现在患者中，限制了其在重复治疗过程中的使用（Curt等人，1984; Goldie & Coldman，1984）。几位作者（综述见Kaye & Merry，1985）已经证明，对DX耐药的一种机制涉及药物的累积和保留受损，并且DX耐药细胞也对具有不同化学结构和作用模式的化合物具有耐药性。在从患者分离的细胞系中（Shoemaker，1983; Merry等人，1986; Louie等人，1986）已经报道了多药耐药性，而没有观察到药物积累减少。可能与药物蓄积减少有关的耐药的另一个特征是分子量为
Resistance to doxorubicin (DX) frequently emerges in patients, limiting its use in repeated courses of treatment (Curt et al., 1984; Goldie & Coldman, 1984). Several authors (for review, see Kaye & Merry, 1985) have demonstrated that one mechanism of resistance to DX involves impaired accumulation and retention of the drug, and that DX-resistant cells are also resistant to compounds having different chemical structures and modes of action.This has been reported in vivo in murine tumours and in vitro inestablished cell lines from animal and human sources. In cell lines isolated from patients (Shoemaker, 1983; Merry et al., 1986; Louie et al., 1986) multi-drug resistance has been reported, whereas reduced drug accumulation has not been observed. Another characteristic of DX-resistance, possibly related to reduced drug accumulation, is enhanced production of a membrane glycoprotein with a molecular weight